Video: Duke’s Grayson Allen Appeared To Intentionally Trip Louisville’s Raymond Spalding

first_imgGrayson Allen on the floor against Rhode Island.PITTSBURGH, PA – MARCH 17: Grayson Allen #3 of the Duke Blue Devils looks on against the Rhode Island Rams during the second half in the second round of the 2018 NCAA Men’s Basketball Tournament at PPG PAINTS Arena on March 17, 2018 in Pittsburgh, Pennsylvania. (Photo by Justin K. Aller/Getty Images)Duke and Louisville are locked into a tight battle at Cameron Indoor Stadium. The Blue Devils led by as many as 14 but now trail late in the contest.During the second half, Duke’s Grayson Allen drove to the basket and was knocked down. While he was on the ground, he appeared to intentionally trip Louisville’s Raymond Spalding, who had corralled the ball and was dribbling up court.yep, that’s a trip by Grayson Allen … https://t.co/hAfZbZaFGb— Ryan Fagan (@ryanfagan) February 9, 2016Definitely looks like he meant to do that.last_img read more

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Ohio State mens basketball loses to Penn State for first time under

Junior forward LaQuinton Ross (10) pushes toward the basket for a shot. OSU lost to Penn State, 71-70, in overtime Jan. 29 at the Schottenstein Center. Credit: Shelby Lum / Photo editorAn inability to put teams away, a lack of toughness or simply missing shots — no matter how you look at it, the Ohio State Buckeyes are no longer undefeated against Penn State with Thad Matta as their coach.Matta’s streak of 17 straight wins against the Nittany Lions came to an end Wednesday, after a jumper in the lane by Penn State redshirt-junior guard D.J. Newbill with 1.9 seconds left in overtime gave them the lead, 71-70. OSU senior guard Aaron Craft was unable to get a shot off at the buzzer and the Buckeyes suffered their fifth loss in six games.“We weren’t the tougher basketball team tonight,” Craft said after the loss. “That’s what it comes down to, 10-point lead with however much time we have left, and we just couldn’t do it.”Newbill carried Penn State down the stretch, scoring 17 of his game-high 25 points in the second half and overtime, including a 3-pointer that tied the game with 11 seconds left in regulation.“This was more than a winnable basketball game,” Matta said after the loss. “It’s one of those things that we’ve got to — we gotta be a tougher physically and tougher mentally basketball team.”The Buckeyes held the lead for the majority of the second half, but were unable to convert when it counted, failing on three attempts before the buzzer sounded in regulation to win.Senior guard Lenzelle Smith Jr. was at a loss for words following the game, but did say the loss “hurts the most out of every game” since he’s been a Buckeye.“This is embarrassing,” Smith Jr. said. “Every other team in our conference is laughing at us right now.”The Nittany Lions (11-10, 2-6), jumped out to an early 15-11 lead on OSU, aided by just 3-10 shooting by the Buckeyes in the game’s first eight minutes.OSU’s shooting percentage improved late in the half, as it used a 7-3 run to take a 35-31 lead into halftime.The Buckeyes (16-5, 3-5) would increase the lead to 11 after two free throws by junior forward LaQuinton Ross, but Penn State would not go away.OSU had multiple opportunities to extend the lead, but was unable to do it and Newbill hit big shots down the stretch to secure the win.Ross led OSU with 16 points and seven rebounds, and Smith Jr. added 15 points of his own in the loss.OSU’s last two losses come by a combined seven points to Nebraska Jan. 20 and Penn State. Both are teams that typically sit near the bottom of the Big Ten standings throughout the course of the season, so are OSU’s problems stemming from a lack of motivation against the traditionally weaker conference opponents?“I would hope not,” Matta said. “I would hope not. Yeah, I would hope not.”For Penn State — who has three conference losses by three points or less — a road win against OSU is “exciting,” Nittany Lion head coach Pat Chambers said.“I’m excited for the kids, for our players,” Chambers said after his team’s win. “It’s so hard, losing by a possession and the ball doesn’t bounce your way … I’m happy for them. They deserved to get one back, so to speak.”For whatever reason, OSU continues to struggle as it makes it way through the rugged Big Ten. The Buckeyes are just 1-5 since starting the season 15-0.“In this league, if you don’t come to play every night, you’re going to lose, as you see tonight,” Smith Jr. said, seemingly shaking off tears. “Top 25 teams at home don’t lose these games. And we lost.”Up next, OSU is set to travel to No. 14 Wisconsin (17-3, 4-3) to take on the Badgers at noon Saturday in Madison, Wis. read more

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AOL has announced plans to build a stateofthear

first_imgAOL has announced plans to build a state-of-the-art, 360-degree content studio in downtown New York.The public-facing studio is due to open this autumn on Broadway and will expand AOL’s “commitment to provide an immersive live and virtual reality experience,” according to the firm.AOL Build, the internet firm’s live interview series, will be filmed at the new 13,400 square foot studio. The series currently produces some four hours of live programming each day and 75 live events per month, with more than 800 episodes having been filmed to date.Jimmy Maymann, executive vice-president and president, AOL Content and Consumer Brands, said that the new studio would connect “the physical and digital worlds for our consumer”.“The studio reflects our commitment to creating immersive live experiences and creating a studio that will serve as a cultural destination, digitally, as well as within New York City.”last_img read more

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Netflixs teen suicide drama 13 Reasons Why was th

first_imgNetflix’s teen suicide drama 13 Reasons Why was the most ‘in-demand’ digital original in Germany in the second quarter of this year, supplanting Q1 favourite The Grand Tour, according to Parrot Analytics’ Global Demand Report for the second quarter.Click to enlargeParrot Analytics analyses the demand for recent popular digital titles across international markets, based on the application of artificial intelligence to expressions of demand across social media, fan sites, peer-to-peer protocols and file-sharing platforms.13 Reasons Why attracted an average of 5.837 million demand expressions in Q2. Amazon’s The Grand Tour, which topped the rankings in Germany in Q1, slipped to fourth place with an average of 2.15 million in Q2, according to Parrot. The Grand Tour did however see a spike in demand expressions in June following presenter Richard Hammond’s car crash while filming the latest series.Amazon has been seen as the leading international SVOD player active in the Germany market, in contrast to many other international markets, where Netflix is seen as the dominant player.However, for the three months to June, Netflix dominated the top 25 most in-demand digital originals in the country in Parrot’s ranking, with House of Cards and Orange is The New Black taking the number two and three spots respectively.Overall, Netflix took 18 of the top 25 slots in the list, with Amazon taking four – for The Grand Tour, The Man in the High Castle, Bosch and Hand of God.Demand expressions for US police procedural drama Bosch jumped 528% when it was released in April. The show performed best in Germany according to Parrot’s ranking, only appearing in its top 25 in two other countries.Netflix’s Gilmore Girls ranking meanwhile outperformed other markets, despite a lack of new episodes.Amazon’s first German original, You Are Wanted, which was released in March, did not appear in Parrot’s top 25 in Q2.Other non-Netflix originals in the top 25 list for Q2 included high-school drama Skam from Norway’s NRK. The series is officially geo-blocked for copyright reasons, but is evidently attracting interest in any case.As part of a collaboration with Parrot Analytics, Digital TV Europe will provide regular updates on the most in-demand shows across key European markets, based on Parrot’s unique datasets.Parrot’s Global Demand Report for the second quarter will be published next week.last_img read more

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Cryptocurrency and the Allure of a Cashless Cannabis Industry

first_img Opinions expressed by Entrepreneur contributors are their own. Green Entrepreneur Podcast Listen Now 3 min read May 24, 2018 Next Article Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. Add to Queue Cannabis Guest Writer Cryptocurrency and the Allure of a Cashless Cannabis Industry –shares dispensaries.com The legal marijuana industry in the United States is awash in cash. Literally.With reports that cannabis businesses generated almost $61 million in tax revenue for California in just the first quarter of recreational marijuana sales, it’s important to remember that the money moving through the marijuana financial system is almost 100 percent in cash. Why? Most banks won’t touch money from legal marijuana businesses because cannabis remains a Schedule I illegal drug at the federal level, meaning banks in the strictest sense risk committing crime providing the industry ordinary commercial banking services. That leaves marijuana entrepreneurs working in a cash-only world.It’s more than just inconvenient. It makes it more difficult to create a safe environment for both employees and customers. It makes it next-to-impossible to get loans to start or grow a business. It also makes tracking marijuana transactions more difficult for businesses and the government.Related: For the Perfect Social-Impact Investment, Look No Further Than CannabisCryptocurrency OpportunityCryptocurrency companies, using blockchain technology, are hoping to step into the gap. At the recent CoinDesk’s Consensus 2018 conference in New York City, many companies touted blockchain and cryptocurrency as a potential cure for the marijuana industry’s financial headache. The conference attracted thousands. More than $17 million in ticket sales were made for the event, held at the New York Hilton Midtown.Blockchain provides a transparent, secure digital transaction record that can be accessed by all users. It’s most associated with Bitcoin. One of the main topics at the conference was how can blockchain be used in the cannabis industry.The idea of cryptocurrency in the marijuana industry gained momentum late last year when researchers at IBM advised the government in British Columbia, Canada, to use blockchain to for seed-to-sale tracking of legal marijuana. Legal recreational marijuana sales are expected to begin in July across Canada.Related: Why Some Veterans Are On the Front Lines to Legalize HempCryptocurrency StartupsNow startups, or more specifically their financial backers, are putting their money behind this theory. Companies that have developed blockchain technology and cryptocurrencies aimed at use in the marijuana industry are springing up like weeds. For examples:Cannabis social media hub MassRoots is now transitioning to a marijuana-focused software company, tying blockchain to its marijuana point-of-sale tracking business, MassRoots Retail.Alt Thirty Six, which uses the cryptocurrency Dash, has partnered with cannabis software company Webjoint to provide access to its digital transaction system for the marijuana-related businesses Webjoint serves in California.Software company Greenstream is building a blockchain-based supply chain system for the cannabis industry that could be accessed by retailers, suppliers and regulatorsRelated: DEA Chief’s Congressional Testimony About Legal Marijuana Angered Some, Baffled ManyIf it all seems a bit like Silicon Valley in the 1990s and 2000s, that’s because it is. The marijuana industry has gone from nowhere to a multibillion-dollar industry in just a few years, yet people are still carrying around their profits in leather satchels. At some point, that is going to end. If the federal government doesn’t provide a solution, then cryptocurrency might.Follow dispensaries.com on Instagram to stay up to date on the latest cannabis news. Marijuana prohibition never stopped marijuana sales. Blocking legal marijuana businesses from the legal banking system isn’t working, either. Image credit: MARK GARLICK | SCIENCE PHOTO LIBRARY | Getty Images Easy Search. Quality Finds. Your partner and digital portal for the cannabis community.last_img read more

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ListenFirsts State of Social TV Report Provides Key Insights To Boost Strategy

first_imgTV Social Audience Growth up 16% in q1 2019, Social Engagement up 6% for TV IndustryListenFirst, the most comprehensive social analytics solution for the enterprise, released its 2019 State of Social TV report with key insights into how consumers are engaging with TV properties on social media, the impact on TV arising from the changes in audience and content quality across social platforms, and the continued rise of Instagram. ListenFirst’s report details the rise in Instagram Stories, fan footprint and engagement, growth in YouTube subscribers and viewership for TV pages, and the uptick in Facebook organic reach and Twitter engagement after major declines.“This report shows the effects that the various social platforms’ changes in the past year had on TV audiences; from Facebook’s algorithm change, to Twitter’s bot purge, to Instagram’s Stories enhancements,” says Jason Klein, Co-Founder and Co-CEO, ListenFirst. “The unique insights in this report can help TV networks understand and capitalize on the platforms, content types, and strategies which are thriving in the current social landscape.”Marketing Technology News: Captify and Publicis Media Release New Research Revealing Global Beauty Trends That Will Transform The Larger FMCG EcosystemKey takeaways from the report include:Instagram and YouTube leading in TV audience growth and interactions: TV pages saw their fan footprint grow 83% on Instagram and 211% on YouTube from Q1 2017 to Q1 2019, with Instagram engagement growing 123%, and YouTube video views up 135% during the same periodOrganic reach on Facebook is on an upwards trend: Organic reach for content published by TV pages on Facebook dropped from 7.85% in January 2018 to a low of 3.66% in November 2018, but has since trended upwards, ending March 2019 at 5.86%; organic reach for branded content posted by TV pages was also up to 11.5% in Q1 2019, up from 9.5% in Q1 2017Streaming networks outpace other networks in social engagement: Social engagement for streaming programs spiked 200% from Q1 2017 to Q1 2019, while Broadcast and Premium Cable programs grew by 55% and 69%, respectively, during the same periodOn Instagram, organic reach dips slightly, but the platform is still growing fast: Despite organic reach for content published by TV pages declining slightly in 2018, from 27.85% in January 2018 to 23.78% in March 2019, Instagram continues to grow with 156% more Stories posted by TV pages in Q1 2019 compared to Q1 2018 and the number of TV programs posting Instagram Stories up 74%Top 5 TV Programs by Interest Score in Q1 2019: Game of Thrones, HBO (9.1M); The Umbrella Academy, Netflix (6.5M); You, Netflix (4.3M); Shadowhunters, Freeform (4.2M); Riverdale, The CW (3.7M)Top 5 TV Network Roll-Ups by Social Engagement Score in Q1 2019: ESPN (564.5M), E! Network (204.4M), ABC (202M), NBC (199.7M), Netflix (187.5M)Marketing Technology News: Arvind Fashions Partners With Nucleus Vision to Create a More Seamless and Personalized Shopping ExperienceListenFirst is the social analytics solution trusted by the largest companies in the world. With a breadth of analytics and domain expertise unmatched in the market, we provide a streamlined solution for leading brands seeking to unlock the power of social insights in an increasingly fragmented world. Founded in 2012, ListenFirst has been honored with multiple accolades including 2018 and 2019 Stevie Awards for exceptional client service, a 2019 High Performer recognition from G2 Crowd, and named one of Inc. 500’s fastest growing companies. ListenFirst clients include major media brands including Turner, AMC Networks, Amazon, A&E Networks, and FOX, and is regularly featured in Variety, Ad Age, The New York Times, and more.Marketing Technology News: RainFocus Recognized as Account-Based Marketing Thought Leader ListenFirstMarketing TechnologyNewssocial analytics solutionSocial TV reportStreaming networksTV audiences Previous ArticleSreekant Lanka Joins iQuanti as Head of Paid MediaNext ArticleComscore Expands Partnership with Lockwood Broadcast Group to Exclusive Measurement Deal ListenFirst’s State of Social TV Report Provides Key Insights To Boost Strategy Performance PRNewswireMay 15, 2019, 3:41 pmMay 15, 2019 last_img read more

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Catalina And Samba TV Partner To Significantly Transform Media And Measurement Landscape

first_imgCatalina And Samba TV Partner To Significantly Transform Media And Measurement Landscape PRNewswireJune 4, 2019, 10:00 pmJune 4, 2019 Marketing Technology News: Alorica Taps Business Transformation Veteran Colson Hillier to Be Chief Marketing Officer“This partnership is a massive leap forward for our industry that is still using legacy tools and methodology. Now we have massive datasets integrated to take the guess work out of media buying decisions and solve the cross-platform measurement problem once and for all,” said Ashwin Navin, founder and CEO of Samba TV. “At Samba, we have a real-time understanding of video and TV audiences at global scale. With Catalina, we marry viewership with real-time purchase data to create the most profound understanding of TV and OTT — the medium used to build brands — with the primary ways brand messages are consumed, creating a huge opportunity to drive more personalization and accountability in the media we enjoy every day.””Together, Catalina and Samba TV are establishing benchmarks and norms for campaign design and reporting that enable networks to track campaign performance to make in-flight optimizations, dramatically upgrading the ability to deliver outcome-based selling,” said Dr. Wes Chaar, Catalina’s Chief Data & Advanced Analytics Officer, who previously led major TV industry initiatives in audience estimation, audience targeting and audience demand modeling.Marketing Technology News: Alpha Software Launches Alpha TransForm, Cuts Build Time for Robust Offline Enterprise Mobile Apps from Months to Hours The combination of Catalina and Samba TV data will provide a comprehensive look at how all advertising, including TV advertising, is driving lift and in-store purchases for advertisers. CPG marketers and their agencies will now have a granular, real-time analysis of campaign performance in stores at the UPC-level allowing them to assess the effectiveness of cross-device campaigns across TV, digital and in-store, reach customers on the right platforms, and optimize campaigns mid-flight.“The melding of Samba TV and Catalina’s advanced analytics capabilities and unparalleled buyer intelligence will allow advertisers to make more informed media and marketing decisions, leading to higher ROI,” said Catalina Chief Executive Officer Jerry Sokol. “Our partnership with Samba TV enables tracking of both brand awareness and ROAS, creating stronger combined capabilities. This partnership is yet another example of how Catalina is dramatically evolving to provide greater value to our customers.” “The Catalina/Samba partnership will also fuel a new take on the Marketing Mix Model. The more granular Consumer Mix Model will use ratings that reflect an individual store’s consumer composition, trading area and ratings in near real time instead of weeks after a campaign ends, which is the current norm,” added Chaar.Howard Shimmel, President of U.S.-based research consultancy Janus Strategy & Insights, has played a key advisory role in the evolution of the Catalina and Samba TV partnership. Shimmel is a recognized expert in data integration, audience buying and ROI/Attribution through his work as Turner’s Chief Research Officer and other leadership positions with Nielsen and Symmetrical Resources.“Catalina and Samba’s collective expertise on buyer behaviors, motivations and lifestyles will allow marketers to be more precise in how they engage audiences to drive purchases, and to fuel the ability of media companies to sell based on outcomes,” said Shimmel. “What truly sets Catalina and Samba apart is the analytics they will apply to the data to help their customers with every stage of planning, execution and measurement.Marketing Technology News: StarfishETL Partners with PeopleSense, Inc.center_img Partnership Enables Media Planning, Execution and Measurement Tied to Outcomes Built on Granular Understanding of What Consumers Watch and BuyCatalina Marketing, the market leader in shopper intelligence and personalized digital media that converts shoppers into buyers, and Samba TV, the leading provider of global TV data and audience analytics, have partnered to integrate shopper behavioral data and video viewership insights at massive, unprecedented scale, encompassing tens of millions of households and billions of data points. Together, the two companies will build advanced analytics tools that fundamentally improve media buying and selling across all marketing channels, including in-store, digital, mobile over-the-top (OTT) and linear TV. analyticsCatalinadigital mediaNewsSamba TV Previous ArticleMedia.net Partners with Amino Payments to Offer Third Party Supply Chain Transparency for All Media.net Marketplace TransactionsNext ArticleB2B Marketers Use AI to Move Beyond the Google/Facebook Duopoly as Research from Marketing Platform InfiniGrow Shows Growth for LinkedIn, Quora, Content Marketing and Eventslast_img read more

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An underused strategy for surge in STDs Treat patients partners without a

first_img This article was reprinted from khn.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorially independent news service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research organization unaffiliated with Kaiser Permanente. Reviewed by James Ives, M.Psych. (Editor)Nov 13 2018If patients return to Dr. Crystal Bowe soon after taking medication for a sexually transmitted infection, she usually knows the reason: Their partners have re-infected them.”While you tell people not to have sex until both folks are treated, they just don’t wait,” she said. “So they are passing the infection back and forth.”That’s when Bowe, who practices on both sides of the North and South Carolina border, does something doctors are often reluctant to do: She prescribes the partners antibiotics without meeting them.Federal health officials have recommended this practice, known as expedited partner therapy, for chlamydia and gonorrhea since 2006. It allows doctors to prescribe medication to their patients’ partners without examining them. The idea is to prevent the kind of reinfections described by Bowe — and stop the transmission of STDs to others.However, many physicians aren’t taking the federal government’s advice because of entrenched ethical and legal concerns.”Health care providers have a long tradition of being hesitant to prescribe to people they haven’t seen,” said Edward Hook, professor at the University of Alabama’s medical school in Birmingham. “There is a certain skepticism.”A nationwide surge of sexually transmitted diseases in recent years, however, has created a sense of urgency for doctors to embrace the practice. STD rates have hit an all-time high, according to the Centers for Diseases Control and Prevention. In 2017, the rate of reported gonorrhea cases increased nearly 19 percent from a year earlier to 555,608. The rate of chlamydia cases rose almost 7 percent to 1.7 million.”STDs are everywhere,” said Dr. Cornelius Jamison, a lecturer at the University of Michigan Medical School. “We have to figure out how to … prevent the spread of these infections. And it’s necessary to be able to treat multiple people at once.”A majority of states allow expedited partner therapy. Two states — South Carolina and Kentucky — prohibit it, and six others plus Puerto Rico lack clear guidance for physicians.A 2014 study showed that patients were as much as 29 percent less likely to be re-infected when their physicians prescribed medication to their partners. The study also showed that partners who got those prescriptions were more likely to take the drugs than ones who were simply referred to a doctor.Yet only about half of providers reported ever having prescribed drugs to the partners of patients with chlamydia, and only 10 percent said they always did so, according to a different study. Chlamydia rates were higher in states with no law explicitly allowing partner prescriptions, research published earlier this year showed.Because of increasing antibiotic resistance to gonorrhea, the CDC no longer recommends oral antibiotics alone for the infection. But if patients’ partners can’t go in for the recommended treatment, which includes an injection, the CDC said that oral antibiotics by themselves are better than no treatment at all.”Increasing resistance plus increasing disease rates is a recipe for disaster,” said David Harvey, executive director of the National Coalition of STD Directors. The partner treatment is important for “combating the rising rates of gonorrhea in the U.S. before it’s too late.”The CDC recommendations are primarily for heterosexual partners because there is less data on the effectiveness of partner treatment in men who sleep with men, and because of concern about HIV risk.Bowe said that even though she writes STD prescriptions for her patients’ partners, she still worries about possible drug allergies or side effects.”I don’t know their medical conditions,” she said. “I may contribute to a problem down the road that I’m going to be held liable for.”In many cases, doctors and patients simply do not know about partner therapy. Ulysses Rico, who lives in Coachella, Calif., said he contracted gonorrhea several years ago and was treated by his doctor. He didn’t know at the time that he could have requested medicine for his girlfriend. She was reluctant to go to her doctor and instead got the required antibiotics through a friend who worked at a hospital.Related StoriesResearchers analyze link between videogame addiction and school inadaptationNew app created to help people reduce exposure to anticholinergic medicationsComputers, games, crafting keep the aging brain sharp”It would have been so much easier to handle the situation for both of us at the [same] moment,” Rico said.Several medical associations support partner treatment. But they acknowledge the ethical issues, saying it should be used only if the partners are unable or unwilling to come in for care.Federal officials are trying to raise awareness of the practice by training doctors and other medical professionals, said Laura Bachmann, chief medical officer of the CDC’s office of STD prevention. The agency posts a map with details about the practice in each state.Over the past several years, advocates have won battles state-by-state to get partner treatment approved, but implementation is challenging and varies widely, said Harvey, whose National Coalition of STD Directors is a member organization that works to eliminate sexually transmitted diseases.The fact that some states don’t allow it, or haven’t set clear guidelines for physicians, also creates confusion — and disparities across state lines.The Planned Parenthood affiliate that serves Indiana and Kentucky sees this firsthand, said clinical services director Emilie Theis. In Indiana, providers can legally write prescriptions for their patients’ partners, but they are prohibited from doing so in Kentucky, even though the clinics are only a short drive apart, she noted. A similar dynamic is at play along the South Carolina-North Carolina border, where Bowe practices.California started allowing partner treatment for chlamydia in 2001 and for gonorrhea in 2007. The state gives medication to certain safety-net clinics, a program it expanded three years ago. However, “it has been an incredibly difficult sell” because many medical providers think “it’s a little bit outside of the traditional practice of medicine,” said Heidi Bauer, chief of the STD control branch of California’s public health department.At APLA Health, which runs several health clinics in the Los Angeles area, nurse practitioner Karla Taborga occasionally gives antibiotics to patients for their partners. But she tries to get the partners into the clinic first, because she worries they might also be at risk for other sexually transmitted infections.”If we are just treating for chlamydia, we could be missing gonorrhea, syphilis or, God forbid, HIV,” Taborga said. But if prescribing the drugs without seeing the patients is the only way to treat them, she said, “it’s better than nothing.”Edith Torres, a Los Angeles resident, said she pressured her then-husband to go to the doctor after he gave her chlamydia several years ago: She refused to have sex with him until he did. Torres said she wanted him to hear directly from the doctor about the risks of STDs and how they are transmitted.If he had taken the medication without a doctor visit, he wouldn’t have learned those things, she said. “I was scared, and I didn’t want to get it again.”KHN’s coverage in California is supported in part by Blue Shield of California Foundation. last_img read more

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Scientists develop monoclonal antibodies combinations that protect animals from Ebola viruses

first_img Source:https://www.usamriid.army.mil/ Reviewed by James Ives, M.Psych. (Editor)Jan 11 2019Scientists from academia, industry, and government have developed a combination of monoclonal antibodies (mAbs) that protected animals from all three Ebola viruses known to cause human disease. Their work is described in two companion studies published online in the journal Cell Host & Microbe.The mAb “cocktail,” called MBP134, is the first experimental treatment to protect monkeys against Ebola virus (formerly known as Ebola Zaire), as well as Sudan virus and Bundibugyo virus, and could lead to a broadly effective therapeutic, according to the authors.Over 20 Ebola virus outbreaks have occurred since the first outbreak was documented in 1976 in the Democratic Republic of Congo, or DRC (formerly called Zaire). The 2013-2016 Ebola epidemic in Western Africa–the largest outbreak to date–sickened more than 28,000 people and caused more than 11,000 deaths. An ongoing outbreak in the eastern Kivu region of DRC is already the second largest on record, according to the World Health Organization.No Ebola virus medical countermeasures have been approved by the U.S. Food and Drug Administration. An experimental vaccine and several experimental therapeutics–including three based on mAbs–are being studied in the field. Despite their promise, all target only a single Ebola virus (Zaire) and are ineffective against the other two.”Developing a single treatment that could potentially be used for patients suffering from all the different types of Ebola viruses is an enormous advancement in the field,” commented John M. Dye, Ph.D. of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), one of the authors.Related StoriesSynthetic antibody rapidly prevents Zika infection in mice and non-human primatesNewly discovered antibody broadly inhibits multiple strains of pandemic norovirusAntibody-drug conjugate effectively targets surface protein in childhood neuroblastomasCiting growing evidence of the value of monoclonal antibodies for treating even the most virulent infections, Dye added, “This discovery has implications not only for the treatment of Sudan and Bundibugyo viruses, but for newly emerging Ebola viruses as well.”The two mAbs that make up MBP134 were previously discovered by the same research team in the blood of a human survivor of the 2013-2016 outbreak in Western Africa and were shown to target key sites of vulnerability shared by Ebola viruses.In the first study, a team led by Kartik Chandran, Ph.D., of the Albert Einstein College of Medicine (Einstein) engineered one of the mAbs to improve its activity against Sudan virus. They demonstrated that this enhanced mAb could work especially well with the second naturally occurring mAb to block infection by all three viruses and protect guinea pigs against both Ebola virus and Sudan virus. Additional modification of both mAbs to harness the power of “natural killer” immune cells enhanced MBP134’s broad protective efficacy in guinea pigs even further.In the second study, a team led by Dr. Zachary A. Bornholdt, Ph.D., of Mapp Biopharmaceutical Inc. (MappBio) evaluated the MBP134 cocktail in large animal models that mimic Ebola virus disease in humans more closely. They found that a single low dose of MBP134 could protect monkeys against all three Ebola viruses associated with human disease, even when treatment was begun 4-7 days after the animals were infected.last_img read more

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Researchers study molecular mechanism of interplay of clock proteins for circadian oscillation

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 7 2019Organisms on this planet, including human beings, exhibit a biological rhythm that repeats about every 24 h to adapt to the daily environmental alteration caused by the rotation of the earth. This circadian rhythm is regulated by a set of biomolecules working as a biological clock. In cyanobacteria (or blue-green algae), the circadian rhythm is controlled by the assembly and disassembly of three clock proteins, namely, KaiA, KaiB, and KaiC. KaiC forms a hexameric-ring structure and plays a central role in the clock oscillator, which works by consuming ATP, the energy currency molecule of the cell. However, it remains unknown how the clock proteins work autonomously for generating the circadian oscillation.Related StoriesResearch sheds light on sun-induced DNA damage and repairResearch on cannabis use in women limited, finds new studyTrump administration cracks down on fetal tissue researchThe research groups at Graduate School of Pharmaceutical Sciences of Nagoya City University and Exploratory Research Center on Life and Living Systems (ExCELLS) and Institute for Molecular Science (IMS) of National Institutes of Natural Sciences investigated this mechanism by native mass spectrometry and nuclear magnetic resonance spectroscopy. They found that KaiC degrades ATP into ADP within its ring structure, which triggers the leaping out of the tail of KaiC from the ring. KaiA captures the exposed KaiC tail, facilitating ADP release from the ring, thereby setting the clock ahead.This “fishing a line” mechanism explains the clockwork interplay of the KaiA and KaiC proteins. Elucidating this mechanism will provide deep insights into not only the circadian clock in cyanobacteria but also that in plants, animals, and humans under physiological and pathological conditions, including jet lag and sleep disorders.Source: National Institutes of Natural SciencesJournal reference: Yunoki, Y. et al. (2019) ATP hydrolysis by KaiC promotes its KaiA binding in the cyanobacterial circadian clock system. Life Science Alliance. doi.org/10.26508/lsa.201900368.last_img read more

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Tesla makes 5000 Model 3s per week but can it continue

first_img CEO Musk: Tesla hits weekly goal of making 5,000 Models 3s Tesla Inc. made 5,031 lower-priced Model 3 electric cars during the last week of June, surpassing its often-missed goal of 5,000 per week. But the company still only managed to crank out an average of 2,198 per week for the quarter. Citation: Tesla makes 5,000 Model 3s per week, but can it continue? (2018, July 2) retrieved 18 July 2019 from https://phys.org/news/2018-07-tesla-3s-week.html © 2018 The Associated Press. All rights reserved. Shares of Tesla Inc. fell around 2 percent to $336.21 in late-day trading Monday.Consumer Edge Research Senior Analyst Jamie Albertine takes a more bullish view. He says Musk doesn’t manage for quarterly results, and believes Tesla can keep producing at the current rate. “I don’t believe their goal was to simply hit 5,000 a week and somehow revert to a lower production rate in the future,” Albertine said. “Their goal is to hit it sustainably with high quality production.”He thinks the company can reach production of 10,000 vehicles per week, or roughly a half-million per year. That will significantly lower capital spending and other expenses so it can turn a profit, said Albertine, who has met with Tesla management.Last summer, when the first Model 3s began rolling off the assembly line, Musk promised to build 5,000 per week by December and 10,000 per week in 2018. But he also warned at the time that Tesla was entering at least six months of “manufacturing hell.”On Monday, the company said it delivered 18,440 Model 3s during the quarter to help satisfy a waiting list that now is around 420,000. Some have been holding out for their cars since March of 2016 when the company first started taking orders. Another 11,166 Model 3s are en route to be delivered to owners, the company said.Currently the cheapest Model 3 that can be ordered costs around $49,000, and they can run upward of $70,000. The company hasn’t said when it will start producing the $35,000 version.Tesla also said it delivered 10,930 Model S sedans and 11,370 Model X SUVs during the quarter.Tesla burned through more than $1 billion in cash in the first quarter.Moody’s Investor Service downgraded Tesla’s debt into junk territory back in March, warning that Tesla won’t have cash to cover $3.7 billion for normal operations, capital expenses and debt that comes due early next year. Tesla said cash from Model 3 sales will pay the bills and drive profits.Musk told investors on a first-quarter earnings conference call that the company relied too heavily on automation. It had to hire more people to work at the factory. Tesla reported making 28,578 Model 3s from April through June, according to its quarterly production release on Monday.The Model 3, which starts at $35,000, is the key to turning Tesla from a niche maker of expensive electric cars to a profitable, mass-market automaker. The company badly needs cash from the compact cars to deliver on CEO Elon Musk’s promise to post a net profit and positive cash flow in the third and fourth quarters. The company has had only two profitable quarters in its 15-year history.To hit the 5,000-per-week mark, Tesla had to erect a second Model 3 assembly line under a tent outside its Fremont, California, factory, and Musk had to spend nights in the plant working out bugs with automation and other problems.The company now says it expects to hit 6,000 Model 3s per week by late August, with its Model 3 assembly line under the plant’s roof reaching 5,000 on its own.”The last 12 months were some of the most difficult in Tesla’s history,” the company’s statement said. Hitting the 5,000 mark “was not easy but it was definitely worth it,” the statement said.Tesla critics now wonder if it can keep up the 5,000-per-week rate, and they question whether it can build high-quality vehicles underneath the heavy-duty tent on the site of what once was a joint-venture factory for General Motors and Toyota.Dave Sullivan, manager of product analysis at AutoPacific Inc. and a former manufacturing manager for Ford Motor Co., said reaching the 5,000-per-week won’t make Tesla profitable by itself. He predicted the company will have trouble sustaining it because parts suppliers will have difficulty keeping up and bottlenecks will develop in the body assembly and paint shops.Tesla, he said, delayed delivery of many of the Model 3s that it made in the second-quarter to boost revenue and achieve the third-quarter profit that Musk promised. The company books revenue when vehicles are delivered.”They did everything they can to artificially pump up the third quarter,” Sullivan said. “I think the fourth quarter will be the quarter of reckoning.”CFRA Research analyst Efraim Levy lowered his rating on Tesla shares from “Hold” to “Sell,” saying he doesn’t see the production rate as “operationally or financially sustainable” in the short term. Over time he expects it to rise, though. Still, the stock is trading above his 12-month price target of $300, so he recommends selling it, he wrote Monday in a note to investors. Explore further In this May 27, 2018, file photo, a 2018 Model 3 sedan sits at a Tesla dealership in Littleton, Colo. Tesla Inc. made 5,031 lower-priced Model 3 electric cars during the last week of June, surpassing its often-missed goal of 5,000 per week. Tesla reported making 28,578 Model 3s from April through June, according to its quarterly production release on Monday, July 2. (AP Photo/David Zalubowski, File) This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

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New York Is Overrun by Rats Yet We Know Almost Nothing About

first_img Chelsea Himsworth, Regional Director for the Canadian Wildlife Health Cooperative, University of British Columbia Rats! They eat our food, chew through our property and spread all sorts of nasty diseases. And they are gross (right?), with those naked tails and quick, unpredictable movements. Rats invade our homes — our castles! — the one place where we should be safe and in control. Over the millennia that we have lived with them, rats have proven themselves virtually impossible to expunge. They are so adaptable that they can exploit and infest virtually every corner of our cities. They avoid traps and poisons and reproduce at such a staggering rate that extermination attempts usually end up being a game of whack-a-mole… or, rather, whack-a-rat. Is it any wonder that many cities seem to be plagued by rats? Or do the cities themselves bear some responsibility for their rat problems? This is what I have been exploring over the past 10 years as a wildlife and public health researcher with the Canadian Wildlife Health Cooperative and the University of British Columbia.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65936-new-york-city-rats-and-humans.html?jwsource=cl已复制直播00:0000:3500:35  Challenges of managing urban rodents For the most part, when it comes to dealing with rats, cities have it all wrong. For example, rat-related issues are addressed using a hodgepodge of unrelated policy and programming. At best, municipal leadership is highly fragmented; at worst, it’s absent altogether. Municipal governments may address rat infestations that occur on public properties or in buildings scheduled for demolition. Local health authorities may address infestations in food establishments or where there is a demonstrated health risk. For the most part, people are left to fend for themselves. Another problem is that we know very little about urban rats. There is simply not enough information about them to answer even the most basic questions like: How many rats are there? Where do they live? Why are they there? Is the problem getting worse? Despite this lack of knowledge, cities are often willing to invest tremendous amounts of time and resources into pest control interventions, such as New York City’s $32 million “war on rats.” It means that cities have no metric to determine the return on their investments, because without knowing what the rat problem looked like beforehand, there is no way of knowing whether an intervention made the problem any better. The cohabiting solution The key to solving this problem may lie in simply changing our perspective. Rather than viewing the city as a place entirely under human control that’s being invaded by rats, we need to recognize that the city is an ecosystem and that rats live here too. This does not mean that we should love rats, nor does it mean that we need to leave them alone. Rather, it shifts the focus to managing the ecosystem of which rats are a part, rather than focusing on the rats themselves. Once we recognize that we are managing a system, it becomes clear that leadership and strategic planning are critical. The very concept of a system is that the whole is more than the sum of its parts; this is the antithesis of the reductionist approach that we’re accustomed to that deals with infestations on a case-by-case basis. Instead, we need to understand the urban ecosystem, just like we would if we were trying to manage polar bear populations in the Arctic or elephant populations on the savanna. This means substantive, long-term investments in collecting data on rat populations and the specific conditions that support them, as well as the impact of any implemented interventions. It also means understanding the interface between rats and humans. For the majority of urban centres, rats pose a relatively minor threat to people. The threats are certainly not in proportion to the amount of negative attention rats receive. This means we need to understand why we find rats so disturbing, and what can be done to reduce that fear. Urban ecologies An ecosystem lens also directs us to look at areas of vulnerability and resilience within the system. When it comes to rats, our homes are the most obvious place of vulnerability, where the relationship between rats and people is least acceptable. However, private residences are often the areas most ignored by municipal powers. Also, rats and rat-related issues disproportionately affect impoverished, inner-city neighbourhoods, and residents of these neighbourhoods are particularly vulnerable to the physical and mental health impacts of living with rats. By identifying and focusing on these highly vulnerable scenarios, cities can start to make meaningful changes in how we perceive and deal with rats. This is not to say the rest of the urban landscape should be ignored. Rather, the identification of particular areas of vulnerability needs to take place within a larger framework that uses ecosystem-based principles to address rats specifically. Examples include changing the way that garbage cans are designed and enacting tougher bylaws that enshrine the right to live in a healthy and rat-free environment. These sorts of policies and programs that increase the resilience of the system have the potential to curtail the physical and psychological damage done by rats. The result is that co-existence with rats will come to seem no more unthinkable than our co-existence with, for instance, squirrels. This article is republished from The Conversation under a Creative Commons license. Read the original article.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoLivestlyThe List Of Dog Breeds To Avoid At All CostsLivestlyUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndolast_img read more

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Defection cases should be disposed of within a timeframe VP

first_imgSHARE Vice President M Venkaiah Naidu on Wednesday expressed concern over the manner in which the Judiciary and Speakers of Legislatures were dealing with cases of political defections and said it needed to be disposed of within a “specific timeframe.” He also advocated a need for an amendment to the Anti-Defection Law, setting a specific timeframe for disposing of defection cases. “Cant we understand when a person changes his (political) flag, colour, leader and slogan and goes ahead,” he asked. Courts too admit petitions and put off the “next hearing” to “next year so and so date,” he said. “They don’t deliver judgements in time. Courts should admit petitions only if they have time and deliver judgement quickly. If they have no time, they should leave it. But they are doing neither this nor that. This is a matter of grave concern,” the Vice President said. Referring to criminal and election-related cases against peoples representatives, he said tribunals and special courts should be set up to deal with and dispose of all such cases within a year. “Priority should be given to cases in which certain persons are facing allegations because they are going to be our leaders. They should be disposed of within one year,” the VP said. COMMENTS Published on December 05, 2018 politicscenter_img courts and legal M Venkaiah Naidu (file photo). SHARE SHARE EMAIL COMMENTlast_img read more

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