APTN National NewsA west coast artist just completed a week long journey in support of the Idle No More movement.Beau Dick walked from the northern tip of Vancouver Island to British Columbia’s capital in the south.And once there Dick performed a seldom seen ceremony aimed at shaming and challenging governments.APTN National News reporter Rob Smith was there to witness the powerful moment.
Rabat – A founding member of the Polisario Front has slammed Algiers’s official position as “observer state” in the Western Sahara dispute.Bachir Dhkil, a founding member of the Polisario Front who fled Tindouf in 1990 over ideological divergences with the separatist group, said in an interview that “Algeria should come to the negotiation table and help find a solution to the conflict it created in the first place.”Dhkil’s remarks come after the latest UN Security Council briefing on the conflict between Morocco and the insurgent group he helped to found in 1973. Dhkil welcomed the UN Security Council’s determination to open negotiations to find a peaceful settlement to the conflict. He said, however, that negotiations should ensure that “Algiers be a full participant and shoulder more responsibility.” Calling Kohler’s briefing an extraordinary development, he said: “The Security Council is getting to understand Algeria’s role in the conflict, which will bring them closer to securing a political settlement.”“Algiers is responsible for the genesis and the escalation of the Western Sahara question…. Algeria not only trains and finances the Polisario Front, but it also gets in the way whenever there are peace talks and prospects of a peaceful settlement.” Dhkil highlighted that there have been in the last 40 years “demographic and geographic changes that show that the Polisario Front is not the sole representative of the people in Western Sahara.”“The most viable and beneficial solution is Sahrawi autonomy under Moroccan sovereignty,” he said.
… in Cuyuni RiverEight persons on Friday morning managed to escape from a burning, sinking vessel on the Cuyuni River in Region Seven (Cuyuni-Mazaruni).The boat engulfed in flamesThe 40-foot iron vessel went up in flames as a result of gas emanating from a hose that slipped out of a stove aboard the boat.According to reports reaching this publication, the boat was at the time travelling along the Cuyuni River, carrying a crew of Venezuelans. Around 06:00hrs on the morning in question, the cook was about to light the stove when the hose attached to the gas cylinder accidentally slipped out.The Guyanese Captain, 26-year-old Paul Lewis, along with the members of his crew were forced to jump into the river, leaving behind the engulfed vessel.The occupants of the boat then managed to swim ashore where they sought assistance. No one was injured.An investigation has been launched. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedVenezuelan authorities say shooting incident reports are falseJune 11, 2016In “latest news”GDF awaits report from Venezuelan officials on recent shooting incident– Brigadier PhillipsJune 8, 2016In “Politics”Venezuelans among 5 in custody following the discovery of grenades, weapons, drugsJanuary 19, 2019In “Crime”
An aerial shot of the Giftland MallManagement of MCG Investments Inc which spearheads the operations at the Giftland Mall has not paid any taxes to the Mayor and City Council (M&CC) for the past four years, as the company states that it is awaiting an agreement to carry out the demanded payments summing up to over $25M. Consultant of MCG Investments Inc, Ray Hugh represented the chairman of the company Roy Beepat at Wednesday’s Commission of Inquiry (CoI) into the puzzling state of affairs at City Hall. Being required to provide an explanation into the back and forth clash between the Town Clerk, Royston King and Beepat, the consultant indicated that a notice was sent to the company for a total of $44,255,183 in 2017. However, a meeting was facilitated between the two on November 2, 2017, where it was decided that all rates and taxes including penalties and interests would be waved completely for the years 2015 and 2016.Hugh said, “It was agreed at that meeting that taxes for the years 2015 and 2016 including interests and penalties would be waved. Interests and penalties for 2017 also would’ve been waved. The demand then [for 2017] would’ve been $11,467,500 and it was agreed that MCG Investments would provide a payment schedule to the Mayor and City Council.” This was so because the company had carried out a private contractual bargain to fix the roads, drains and to install streetlight. Garbage collection was also done privately throughout the area and as such, the company was not benefitting from any services that were provided by the Council. Additionally for 2017, Giftland Mall would only be required to pay a sum of $11,467,500 after the interests and penalties would’ve been waved. “M&CC had done nothing for that area. No lighting or drainage. It was all done by MCG Inc, garbage collection, disposal is done on a private contractual basis. That road also services a gated community in the rear of the mall,” said the consultant. King was required to respond via a letter after the engagement to confirm the agreements and a schedule would subsequently be sent by Beepat, verifying how the payments would be made.However, King made no attempts to answer to the decision that was taken until April of this year, where he indicated via a letter that the agreement ‘no longer stood’ because of the lapse of time and ‘certain circumstances’. The document further mentioned, “The Chairman of the Finance Committee had agreed to meet and discuss with you the way forward to settle your accounts with the Georgetown.”The Commission also heard that another letter was issued by the Town Clerk the following May, stating that the Council took a decision on April 28, to impose a fee of $25,263,750 instead of the previously agreed sum of $11,467,500. The company has not paid any taxes since 2015 and is contending that City Hall has to come to the table with an explanation as to why the extra costs were attached to the initial sum. Hugh would’ve indicated that Beepat had written several letters to the Town Clerk, informing him of the arrangement that was set but there was no reply.When the matter was raised by the legal assistant, Sherwin Benjamin as to why the principle rates for the past four years were not paid, Hugh responded, “I don’t see without an agreement, just going ahead and paying something because they can say if you pay part of it, pay the whole thing. The agreement was that after we received the letter [from the Town Clerk], we would send in a payment plan.”Benjamin posited, “Every citizen of Georgetown can say that there isn’t an agreement so they’re not paying taxes. That would be a sad day for this town. At the very least, your company should pay the bear taxes for 2017.” As a consultant by profession, Hugh was probed to give a recommendation to the council to which he stated, “I would say clean it up. It seems like everyone is doing their own thing at City Hall and we need someone to make sure that proper plans, structures and an overview is put in place.”To date, monies are owed by the Giftland Mall at Turkeyen on the East Coast of Demerara (ECD) for taxes dating back to 2015. (Rupa Seenarine) Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedGPL says ‘moving forward’ to buy power from Giftland MallSeptember 5, 2019In “Business”US$30M Giftland Mall to employ over 2000 GuyaneseMarch 13, 2015In “Business”Govt’s closure of road for state function severely affecting business – Giftland Mall ChairJanuary 29, 2019In “Business”
A new study has delivered an unprecedented account of water resources in Western Australia’s Pilbara region, providing an in-depth understanding of local water systems and the potential impacts of climate change on water availability. The Pilbara Water Resource Assessment project, a A$3.5 million partnership between CSIRO, BHP Billiton and the Government of Western Australian, will allow water managers and local industry to plan for future water use in an area rich in resources and environmental assets.“Knowing how the water systems operate right across the region, such as how groundwater is affected by rainfall and storm events, helps with the planning and management of local water use,” said CSIRO’s Dr Don McFarlane, the project leader. “By helping to put a lot of smaller local water resource investigations into a broader context, this study provides a strong framework for water managers and local industries well into the future.”BHP Billiton said its contribution to the project reflected the Company’s commitment to responsible and sustainable water use at its Pilbara-based iron ore operations. “The study provided an opportunity to discuss our regional water resource key considerations and highlight the areas requiring further investigation,” said Blair Douglas, BHP Billiton Iron Ore’s Water Practice Lead. “The collaboration between industry and scientists in both the state and federal governments has delivered a comprehensive outcome. The fundamental science delivered by the study can be applied by industry to achieve practical and sustainable water management solutions.”The study revealed some of the mechanisms responsible for filling the Pilbara’s groundwater stores. It found that between 8 and 30 mmm of rainfall is required before runoff starts in most catchments, which leaks through streambeds to provide the main source of aquifer replenishment. Water from these shallow alluvial aquifers then recharges deeper paleochannels or dolomite aquifers, which can store large quantities of water in inland areas.It also examined how ecosystems dependent on the region’s groundwater sources have changed as a result of wet and dry periods, finding they expand during wet periods and contract during dry periods but have remained relatively stable in number over the past 23 years.The Assessment was funded by a A$0.5 million contribution from BHP Billiton and A$1.5 million each from CSIRO and the Government of Western Australia through the Royalties for Regions program. The research project was led by CSIRO and overseen by officers from the Department of Water, BHP Billiton, the Pilbara Development Commission and the Water Corporation.
A new update to this MineSight planning solution is the latest in a busy year of improvements. It comes ahead of the publication in February of International Mining’s February review of mine planning software.Block model scheduling is now a part of MineSight Schedule Optimer, (MSSO) following the release of MSSO Version 9.3 by Hexagon Mining. MineSight is Hexagon Mining’s comprehensive modelling and mine planning software platform. MSSO is popular product for short, medium, and long-term planning. It determines the most productive cut mining sequence to achieve the highest project profitability, and then generates practical schedules.Block model scheduling allows you to import a range of blocks from a block model, and aggregate the blocks into full-bench scheduling units or smaller scheduling units by defining the number of blocks in each direction. Planners can generate schedules by importing blocks from the model and obtain a more accurate cycle time from a block to each destination. Scheduling results can be written back to the block model for validation and downstream production scheduling and operations.Version 9.3 includes a standalone package option, which includes a MineSight Project Viewer for users to visualise the geometries and scheduling results, and select or digitise a ramp, lead line, road, and point, etc. This release follows closely on the heels of Version 9.2, which allows users to specify the period availability of haulage roads. If a road becomes unavailable in a period, the scheduler will automatically pick another road that leads to the optimal schedule. Version 9.2 allows the definition of variable wait, spot, and dump time by destinations to consider the different geometric condition of each destination.End of Period (EOP) maps can be generated for pits and dumps in Version 9.2. EOP maps include surfaces and/or solids (incremental or aggregated by period). Other improvements in 9.2 include Item Weighted Average (IWA), full report templates, and more accurate in-pit haul path cycle time calculation. In response to customer feedback, Hexagon Mining delivered 10 releases of MineSight Schedule Optimizer in 2015, with about 30 new features. The company says “2016 promises to be just as busy!”
← Previous Story LNH: Strong PSG Handball alone at the TOP Next Story → EHF CL: Kielce routine win over Kristianstad Here is complete schedule of the VELUX EHF Champions League Round 4 for upcoming weeekend.GROUP A:Orlen Wisla Plock – THW Kiel (Saturday 20.45)MVM Veszprem – Besiktas MOGAZ (SU, 15.00)PSG Handball – PPD Zagreb (17.00)SG Flensburg – RK Celje PL 18.30GROUP B:Vive Tauron Kielce – IF Kristianstad (SA, 16)RK Vardar – Rhein Neckar Lowen 17.30FC Barcelona Lassa – Montpellier 19KIF Kolding – MOL PICK Szeged 16.50 (SU)GROUP C:Meshkov Brest – Naturhouse La Rioja 31:33Tatran Presov – RK Vojvodina 15.30 (SA)FC Porto – Chekovskie Medvedi 1GROUP D:Kadetten Schaffhausen – HC Motor Zaporozhye 30:27Skjern – RK Metalurg (SU 15.10)Elverum – Minaur Baia Mare 16.15
59 candidates declare for European Parliament elections in May 13 Irish MEPs will be elected when voters go to the polls on 24 May. 46 Comments Monday 15 Apr 2019, 3:31 PM Share90 Tweet Email Image: Laura Hutton/Photocall Ireland By Cónal Thomas https://jrnl.ie/4592499 A TOTAL OF 59 candidates will contest the European Parliament elections across three constituencies after nominations closed today. In the Dublin constituency where there are four MEP seats up for grabs, 19 candidates have declared their candidacy ahead of elections on 24 May.These include former SDLP leader Mark Durkan, who is running for Fine Gael, incumbent Sinn Féin MEP Lynn Boylan and independent Senator Alice-Mary Higgins. Earlier today, Independents 4 Change TD Clare Daly announced her bid for a European seat in Dublin while her party colleague Mick Wallace TD announced his intention to run in the Ireland South constituency where there are five seats available and 23 candidates. Other contenders in this field include Fianna Fáil TD Billy Kelleher, Green Party Senator Grace O’Sullivan and sitting Fine Gael MEP Deirdre Clune. Candidates in the Midlands North-West constituency – where there are four seats up for grabs and 17 candidates – include former presidential candidate Peter Casey, incumbent MEP Luke ‘Ming’ Flanagan and Fine Gael’s Maria Walsh. A total of 13 MEPs will be elected in Ireland when voters go to the polls in May. 17,696 Views Apr 15th 2019, 3:31 PM Image: Laura Hutton/Photocall Ireland Short URL Tweet thisShare on FacebookEmail this article
Stay on target Workers preparing to place new water pipes have found an ancient burial site with “human sacrifice” bones in the U.K.The site, which was located in Childrey Warren, Oxfordshire, contained about 26 human skeletons believed to be from the Iron Age and Roman periods, Fox News reported. The victims’ bones, which were discovered during a multi-million dollar Thames Water project, might have come from ritual burials conducted almost 3,000 years ago, said a Thames Water Utilities Limited press release.Photo Credit: Thames WaterThis gruesome find revealed one female skeleton, which was found buried with her feet cut off and placed side by side, while another unidentified skeleton was discovered with the skull placed below its feet. Other objects at the ancient site included evidence of animal carcasses, dwellings, and household items including cutting implements, a decorative comb, and pottery.“The Iron Age site at Childrey Warren was particularly fascinating as it provided a glimpse into the beliefs and superstitions of people living in Oxfordshire before the Roman conquest,” Neil Holbrook, chief executive of Cotswold Archaeology, said in the press release. “Evidence elsewhere suggests that burials in pits might have involved human sacrifice.”He added, “The discovery challenges our perceptions about the past, and invites us to try to understand the beliefs of people who lived and died more than 2,000 years ago.”Photo Credit: Thames WaterCotswold Archaeology carefully removed the items so they can be forensically examined, enabling Thames Water Utilities Limited to start laying a 3.7-mile pipe which will give nearby villages water taken from groundwater boreholes located near the River Thames.“This is a £14.5 million (approximately $19 million) project which is going to have real benefits for the environment by reducing the need to take water from the Letcombe Brook, a chalk stream which is a globally rare and highly important habitat for us to protect,” Chris Rochfort, Thames Water environmental manager, said in the press release. “As a result, future generations will be able to enjoy it for years to come – and now they can also learn about their village’s secret history.”More on Geek.com:Scientists Reveal World’s ‘First’ 3D-Printed HeartOil-Eating Bacteria Found in World’s Deepest Ocean TrenchDeclassified U2 Spy Plane Photos Reveal Forgotten Historic Sites Watch: Dolphin Leaps Feet Away From Unsuspecting SurferNASA Says 2 Asteroids Will Safely Fly By Earth This Weekend
Facebook Now Playing Up Next Twitter Now Playing Up Next Mike Tedesco RELATED ARTICLESMORE FROM AUTHOR Madison Square Garden Pays Tribute to Roman Reigns Now Playing Up Next Google+ Pinterest Now Playing Up Next The Miz Vince McMahon Sends Supportive Message To Roman Reigns WWE Rescheduling San Jose NXT WWE announced on last night’s episode of RAW that the King of the Ring Tournament is coming back starting on next Monday’s RAW on August 19 from St. Paul, Minnesota.The King of the Ring Tournament will feature 16 wrestlers (8 from RAW, 8 from Smackdown Live) competing in a single elimination bracket tournament until one Superstar is left. That person is then crowned the King of the Ring.WWE last held the tournament in 2015, which was won by Wade Barrett. The King of the Ring tournament was a featured PPV for WWE from 1993 to 2002. The tournament itself was started in 1985 and would be a yearly event except in 1990 and 1992. After the PPV ended, the tournament would come back as part of the television shows in 2006, 2008, 2010, and most recently in 2015.Many WWE Hall of Famers have won the tournament or used it as a catapult to greater success. People that have won it include Harley Race, Randy Savage, Bret Hart, Owen Hart, Stone Cold Steve Austin, Triple H, Kurt Angle, Edge, Booker T, and Brock Lesnar.Here is the list of Superstars appearing in this year’s King of the Ring tournament:RAW– The Miz– Ricochet– Cedric Alexander– Samoa Joe– Drew McIntyre– Baron Corbin– Sami Zayn– CesaroSmackdown Live– Kevin Owens– Ali– Apollo Crews– Chad Gable– Elias– Andrade– Buddy Murphy– Shelton BenjaminRecommended videosPowered by AnyClipMadison Square Garden Pays Tribute to Roman ReignsVideo Player is loading.Play VideoPauseUnmuteDuration 0:34/Current Time 0:00Loaded: 100.00%0:00Remaining Time -0:34 FullscreenUp NextThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Replay the list WWE Clash of Champions Results – 9/15/19 (Rollins vs. Strowman, Kingston vs. Orton) Videos Articles WhatsApp Videos Articles Xavier Woods Triple H Ronda Rousey To Make WWE Debut At WrestleMania Now Playing Up Next Is WWE Losing Its Audience? Wrestleview Live #65: Reviewing and discussing WWE Clash of Champions from Charlotte Videos Articles Video: Watch the live WWE Clash of Champions Kickoff Show from Charlotte tonight
Search teams looking for a man missing from the Lewis River RV Park for several days found his body early Wednesday in the Lewis River, according to the Cowlitz County Sheriff’s Office. Deputies said they did not suspect foul play.The sheriff’s office said the park manager contacted deputies late Tuesday to report one of the park residents, Stephen Glen Orley, 69, had not been seen for several days.The manager said Orley had health problems and dementia, and his car was left with his trailer. Neighbors told a deputy they hadn’t seen him, and another neighbor said they heard Orley yelling early Tuesday morning, but dismissed it because it wasn’t uncommon, given his dementia.Local hospitals and relatives said they hadn’t seen him either, the sheriff’s office said.Cowlitz County search and rescue volunteers combed the area Wednesday morning and found his body in the river, about 100 yards downstream from his trailer.The sheriff’s office said Wednesday afternoon deputies had yet to examine Orley’s body, but said there were no initial indications his death was connected to any crime.
South Korea managed to gain a shocking win against Germany and eliminate the world champions by achieving this result – and Son Heung-Min admitted that it is like a dream coming true.The Asian team had been already eliminated after being beaten 1-0 by Sweden a 2-1 by Mexico – but despite that, they tried their best and achieved a historic result against a very strong team as they scored both of their goals in the dying minutes.The Tottenham striker spoke about this huge win as he said, according to Reuters:“We beat the world champions and normally it’s a dream and we can be proud of the team.”Top 5 Bundesliga players to watch during the weekend Tomás Pavel Ibarra Meda – September 11, 2019 With the international activity cooling down for the next month, we go back to the Bundesliga’s Top 5 players to watch next weekend.The German…“Of course it’s disappointing because we lost in the group but I think I can be proud after this win and we can be proud of this win.”“We beat the world champions from the last World Cup and now I’m looking forward to the next World Cup.”“I’m a bit disappointed because we have a lot of good players and we couldn’t show them in the next round, but we’re looking forward to the next games.”
Showcases How Soy Combines Good Taste with Health Benefits in U.S. and OverseasTo highlight the many great tasting soyfoods and their health benefits, the American Soybean Association (ASA) hosted its first Soyfoods Luncheon today in Washington, D.C. Members of Congress and their staff sampled modern soyfoods and received information about soy’s health benefits for domestic as well as international consumers. Representative Jo Ann Emerson (R-MO) served as the Congressional host of the event. One of Washington, D.C.’s premier restaurants, Kinkead’s, and Executive Sous Chef Todd Schiller conducted a cooking demonstration at the luncheon that also featured many recipes from award-winning chef and cookbook author Dana Jacobi.White Wave, Solae, Soyatech, Inc., and the Soyfoods Association of North America (SANA) sponsored the event that showcased many soy products that helped fuel the 16.9 percent increase in U.S. soyfood sales between 2000 and 2001. U.S. soyfood sales reached $3.234 billion in 2001, according to SANA. Internationally, soy is gaining recognition as an affordable source of complete protein that can quickly fortify foods that are already popular in countries ranging from Afghanistan to Zimbabwe. The United States exported about 40 percent – equivalent to about 29.9 million metric tons – of its 2001 soybean crop.”ASA is hosting this reception to communicate the proven benefits of soy,” said ASA Chairman Bart Ruth, a soybean grower from Rising City, Neb. “Soy’s value in the battles against heart disease and some forms of cancer is widely known, and now there is growing recognition of soy’s ability to help people with HIV/AIDS. Soybean growers are pleased that their product can do so much good for so many people.”Domestically and internationally, soy can complement or fortify diets, rather than compete with products that are already consumed. U.S. federal nutrition programs, like the school lunch program, are an example of where the addition of soy can benefit existing menus. The ASA’s position is that fortified soymilk should be included as a choice in federal nutrition programs. This initiative is completely focused on the population of children who are lactose intolerant or do not currently drink milk for other reasons.Internationally, there is even more potential for soy’s nutrition to benefit children and adults as the world struggles with dire food shortages on multiple continents. In addition to many traditional soy products, like corn-soy blend, the U.S. Agency for International Development (USAID) and the U.S. Department of Agriculture (USDA) have approved the use of five high-protein soy products for use in their food assistance programs. The products are defatted soy flour, textured soy protein, soy protein concentrates, isolated soy protein and soymilk replacer.Nutrition is gaining greater recognition as a front-line defense in efforts to help the 42 million people who now have HIV/AIDS. Soy is well suited to meet the protein, calorie and other nutritional requirements for people with HIV/AIDs. Protein requirements of HIV-infected persons jump to 50-100 percent higher than for uninfected persons, according to Food and Nutrition Technical Assistance (FANTA). Already, the vast majority of recommended calorie-containing nutritional supplement products contain soy ingredients for optimum nutrition.President George W. Bush announced a new Emergency Plan for AIDS Relief in his State of the Union address presented in January. Congress is now considering his request for $15 billion over the next five years to help people who currently have AIDS as well as slow the spread of the disease. This new initiative includes care for 2 million people living with the virus and 10 million orphans affected by the pandemic in 14 African and Caribbean countries. The President seeks to fund this initiative in addition to the Global AIDS Fund whereby the United States and many other nations support programs in 50 countries.The United States Leadership against HIV/AIDS, Tuberculosis, Malaria Act of 2003 (H.R. 1298), authorizes the President’s $15 billion initiative to fight the global AIDS pandemic. H.R. 1298 directs USAID to conduct nutritional feeding any time there is a drug therapy treatment in place. The ASA supports these provisions.The ASA is the policy, domestic marketing, new uses, research and international marketing advocate of the U.S. soybean farmer. Because of soy’s important role in improving nutritional profiles of international diets, the ASA, the United Soybean Board, and state soybean organizations launched the World Initiative for Soy in Human Health (WISHH) in 2000. The program is helping America’s soybean growers build more bridges between America’s bounty and sustainable nutrition programs in countries where rapidly growing populations of all income levels can benefit from soy in their diets.
FORT LAUDERDALE, FLA. (WSVN) – A man accused of driving a car into a lake and killing his three passengers, back in January, appeared in court Friday.Twenty-four-year-old Deshawn Prince is being held on 11 charges, including three counts of vehicular homicide and three counts of DUI causing death.According to investigators, Prince drove a car into a Lauderhill lake along Northwest 44th Street and Inverrary Boulevard West.Police found Prince on the side of the pond uninjured. Prince’s attorneys contend that he did try to help and tried to save his three friends when he crashed his car into the lake. The families of the victims don’t believe that.Said the judge, “This case, there was three deaths and a substantial blood alcohol level as well as cannabis in his system.”The victims included 22-year-old Shaquille Barrows, 15-year-old Tyrese Barrows and 25-year-old Nathaniel Morgan. “He’s gone,” said Ann Marie Bryant, who lost her son. “You know, it’s good that he is where he is, but it doesn’t bring [my son] back.”Donna Legrand, who lost both of her sons, spoke in court, Friday. “I, personally, don’t think that he should get out,” she said. “My life has been a living hell since January 10 and 11. He has no remorse. He should not be out in society. He should definitely not be driving. He lied to the police since day one. I don’t think he should be out, like I said. I lost a 14-year-old and a 22-year-old. I have two granddaughters without a father.” In court today, Legrand said, “I can’t even go in Tyrese’s room. Everything is the same. It hurts me and my husband, the whole family, and I don’t think he should be out in society.”“Sleeping is impossible,” said Bryant. “There’s a hole … That was my first child.”Prince is being held on a $527,525 bond. Another hearing is expected in the next few weeks.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Certified results from the recent election were 122 votes in favor of keeping alcohol in Emmonak and 103 votes against. The community has a total of 502 eligible voters, according to local officials.Emmonak is a community of more than 700 near the mouth of the Yukon River and had a long history of prohibiting alcohol. But voters in 2016 – also by a slim margin – approved alcohol sales at a facility run by the local government.Emmonak’s City Clerk, Mona Andrews, has worked for the community during its last two local option elections.“The first outcome, I thought it would pass, it was so close,” Andrews said. “The second round I was disappointed again. This time I had put signs everywhere in Emmonak to make sure people knew. I’m just sad that the results turned out for Emmonak to still be damp”Andrews says Emmonak is working on ways to remove bootleggers and address regional concerns over alcohol in the community. She says surrounding villages have complained about the negative effects alcohol from Emmonak is having on their residents.Emmonak’s tribal leaders and other stakeholders plan on holding community discussions regarding alcohol.Andrews expects continued efforts to restrict alcohol in the community. According to Alaska Statutes, Emmonak can start a new petition to hold another election as soon as the past results have been certified. Voters in the Western Alaska community of Emmonak have narrowly decided to continue restricted alcohol sales and remain a so-called “damp” community under local option laws.
Three Washington-area residents who use their unique talents, resources and abilities to increase opportunities for women and girls will receive Visionary Awards at the Washington Area Women’s Foundation’s annual Leadership Luncheon Oct. 23 at the Grand Hyatt Washington. The luncheon’s theme is “Here. Now. For Her.” and builds on the national momentum for the economic advancement of women and girls. The Visionary Awards recipients are recognized for their commitment to advancing women and girls in the Washington region. For more information about the Washington Area Women’s Foundation, visit http://thewomensfoundation.org.
The Baltimore County Council on June 5 tabled action on taking up a federal program which would have required corrections officers at the county’s detention center to determine the immigration status of detainees.The council voted 5-2 to table action on a program established under Section 287g of the U.S. Immigration and Nationality Act, which also would have given the Department of Homeland Security authority to deputize state and local law enforcement agents to act as immigration officers. Baltimore County Councilmen Todd K. Crandell (R-District 7) and Wade Kach (R-District 3) were the only two to vote against tabling the measure. Baltimore County Executive Kevin Kamenetz (Courtesy Photo/baltimorecountymd.gov)Baltimore County Executive Kevin Kamenetz staunchly opposed his jurisdiction joining Frederick and Harford counties in taking up the federal program. Anne Arundel County has applied for approval to join the program, but faces opposition from the ACLU of Maryland, which has created a petition requesting the county to withdraw its application. Kamenetz had threatened to veto any county bill seeking entry into the program. An executive order issued by Kamenetz in April bars the detaining of any county inmate past their scheduled release date for reasons connected to their immigration status.“The Council’s action affirms support for my Executive Order, a responsible and public safety policy that protects the rights of individuals,” Kamenetz wrote in a tweet following the county vote. “The misguided policy was more about spreading Donald Trump’s divisive policies to our country than doing what is best for our residents.”The legislation could have cost taxpayers millions of dollars annually for the additional detainment of inmates based on their immigration status, as well as costs connected to potential lawsuits against the county for the unlawful detainment.According to the Maryland State Board of Elections, at the time of last November’s general election, 56 percent of Baltimore County residents were registered as Democrats. Under the 2010 census, just 4.2 percent of the county’s 805,029 residents identified themselves as being Hispanic or Latino.
A modified LEGI model and computer simulation that reproduces both persistent cell migration and oscillations. A diagram of the modified LEGI model that involves the production of both excitation and inhibitory signals in the frontal region, followed by the transport of inhibitory signals away from the front to maintain frontal protrusions and cell polarity in control cells. In nocodazole-treated cells, the impairment of the transport and the resulting accumulation of inhibitory signals at the front act against the excitation signals and cause the head to switch into a tail (A). Computer simulation of this mechanism for cells in 1D successfully reproduces both persistent migration (kymograph in B) and oscillations (kymograph in C). Diagrams of cell location and shape, colored to show the heat map of net signals, show the dynamics of net signals before and after the treatment of nocodazole (D). In addition, the period of oscillation increases upon the impairment of the generation of inhibitory signals (by increasing the delay), which mimics the effect of blebbistatin (kymograph in E). a.u. stands for an arbitrary unit used in computer simulation. See also Fig. S6 and Movies S4–S6. Credit: Zhang J et al. (2014) Microtubules stabilize cell polarity by localizing rear signals. Proc Natl Acad Sci USA 111(46):16383-16388. Explore further (Phys.org)—Microtubules – tubular polymers of tubulin (a globular protein) that are a component of the cytoskeleton found throughout cell cytoplasm – are involved in a range of cellular functions, including the movement of secretory vesicles, organelles, and intracellular substances; cell division (mitosis and meiosis), including the formation of mitotic spindles; and cell polarity, which refers to spatial differences in cellular shape, structure and function. However, the nature of the role of microtubules in cell polarity has yet to be clarified. At the same time, cell migration plays an essential role in many important physiological processes, such as embryogenesis, wound healing, and immune responses; in engineering applications such as tissue regeneration; and, when defective, in causing severe problems such as birth defects, vascular disease and tumor metastasis. A key area for investigation in the linkage between cell polarity and cell migration is that directional cell migration requires a defined polarity, generated by an integrated network of signals, adhesions (the protein-based binding of a cell to a surface or substrate) and cytoskeleton. Play A representative RPE-1 cell expressing RFP-zyxin and migrating on 1D strip, treated with nocodazole to induce oscillations. The movie shows the redistribution of zyxin upon nocodazole treatment. Related to Fig. 2. Credit: Zhang J et al. (2014) Microtubules stabilize cell polarity by localizing rear signals. Proc Natl Acad Sci USA 111(46):16383-16388. Moving forward, Wang tells Phys.org, the researchers would like to drill down the molecular mechanism and cellular structures for polarity control. “We found that a focal adhesion protein, zyxin, has some unique properties that parallel cell polarity, suggesting that it may be a key ‘readout’ of the LEGI mechanism as well as the control factor for cell polarity – and we’re now in the process of elucidating its functional role in cell polarity. In addition,” he continues, “while centrosomes have long been speculated to control cell polarity, we’re trying to establish a logical connection between centrosomes and the LEGI mechanism.” (The centrosome is an organelle that serves as the main microtubule organizing center, or MTOC, of the animal cell, where microtubules are nucleated.) Wang adds that they may also investigate fine regulation of cell migration based on the manipulation of microtubules or motor molecules without total depolymerization of microtubules, and a ‘biological clock’ based on oscillating polarity.Wang says that there are other areas of research that might benefit from their study. “Understanding the control mechanism of cell migration can greatly facilitate migration dependent processes such as tissue engineering and cancer treatment3,4. In addition, the elegant switch between positive and negative feedback may impact bio-inspired engineering, in which a man-made machine may use a biomimetic control mechanism to achieve innovative functions.”Specifically, Phys.org asked Wang if their findings might pertain to the observation that metastasis and neuroneogenic targeting have similar behavioral properties, and may share what has been termed an ancient genetic toolkit5 that plays a role in cancer. “Yes,” Wang affirmed. “Metastasis is driven by the migration of tumor cells. Our findings improve the understanding of the internal control circuit for cell migration, which will benefit the understanding and treatment of metastasis, – such that conditions that reduce the stability of tumor cell migration may be deployed for cancer treatment.” RPE-1 cells in 50 μM ciliobrevin D. Kymograph shows a representative RPE-1 cell treated with ciliobrevin D oscillating in a manner similar to those treated with nocodazole. (Scale bar, 50 μm, 60 min.) See also Figs. S1 and S7 and Movie S1.Credit: Zhang J et al. (2014) Microtubules stabilize cell polarity by localizing rear signals. See also Figs. S1 and S7 and Movie S1. Proc Natl Acad Sci USA 111(46):16383-16388. More information: Microtubules stabilize cell polarity by localizing rear signals, Proceedings of the National Academy of Sciences (2014) 111(46):16383-16388, doi:10.1073/pnas.1410533111Related:1Quantitative Studies of the Growth of Mouse Embryo Cells in Culture and their Development into Established Lines, Journal of Cell Biology (1963) 17(2):299–313, doi:10.1083/jcb.17.2.2992Periodic migration in a physical model of cells on micropatterns, Physical Review Letters (2013) 111(15):158102, doi:10.1103/PhysRevLett.111.1581023Race to the top: Decoding metastasis, Medical Xpress April 29, 20114Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape, Proceedings of the National Academy of Sciences (2011) 108(17):6853-6856, doi:10.1073/pnas.11028081085Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors, Physical Biology (2011) 8:015001, doi:10.1088/1478-3975/8/1/015001 Recently, scientists in the Department of Biomedical Engineering at Carnegie Mellon University, Pittsburgh obtained a series of analytical and experimental results showing that:Cells on micropatterned linear strips change from highly persistent migration into striking oscillations upon the disassembly of microtubulesPositive feedback in the local-excitation-global-inhibition, or LEGI, mechanism – which is responsible for migration persistence, and in which the response to a stimulus (such as chemotaxis, the movement of an organism in response to a chemical stimulus) is mediated through the balance between a fast, local excitation and a slower, global inhibition process – might be converted into negative feedback to drive oscillations upon the disassembly of microtubulesMicrotubules facilitate the transport of inhibitory signals and their global distributionFeedback in the integrated control circuit may be either positive or negative, depending on the relative position of excitation and inhibitory signalsThe scientists therefore concluded that these findings provide valuable insights into the role of microtubules in the control circuit of cell migration.Prof. Yu-Li Wang discussed the paper that he, Graduate Research Assistant Jian Zhang and Project Scientist Wei-Hui Guo published in Proceedings of the National Academy of Sciences, starting with the challenges involved in the team finding that depolymerization of microtubules caused cells to change from persistent to oscillatory migration. The issue, Wang tells Phys.org, is that without confining cell migration along a one-dimensional (1D) strip, depolymerization of microtubules simply causes cells to lose directional migration without showing recognizable oscillations – so confinement to 1D is required for the highly persistent migration before microtubule depolymerization as well as the oscillatory migration after depolymerization. “This is most likely due to limiting cell migration to two opposite directions,” he explains. “Oscillations become difficult to observe when the cell is able to switch among many different directions. Moreover,” he adds, “our observation was also facilitated by using the RPE-1 cell line, which has a relatively short oscillation period such that multiple cycles of oscillation may be observed before the cell enters division phase. RPE-1 cells therefore allowed unambiguous confirmation of the initial observation made with NIH/3T3 cells.” The retinal pigment epithelium, or RPE, is the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells. 3T3 cells – from a cell line originally established in 1962, and published1 in 1963, by George J. Todaro and Howard Green at New York University School of Medicine – has become the standard fibroblast cell line. (Fibroblasts are the most common connective tissue cell in animals.) PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen Play Persistent migration and oscillation of RPE-1 cells. The movie shows representative RPE-1 cells migrating persistently as a control or showing oscillations when treated with nocodazole or ciliobrevin D on 1D strips. Related to Figs. 1, 2, and 6. Credit: Zhang J et al. (2014) Microtubules stabilize cell polarity by localizing rear signals. Proc Natl Acad Sci USA 111(46):16383-16388. The second analytic conclusion was based on a primary difference between cells and man-made machines – the former involve dynamic localization of structures and signals, while the latter usually consist of components with a fixed location and geometrical relationship – so depending on the relative position of excitation and inhibitory signals in cells, the resulting feedback in the integrated control circuit may be either positive or negative. In contrast, the lack of dynamic localization in most man-made machines keeps them from exhibiting this conversion. “Although rarely realized in man-made machines, transport-dependent conversion between positive and negative feedback in the cell makes intuitive sense for regulating dynamically localized activities.” Wang points out. “When negative signals are transported away from positive signals, it creates a positive feedback by suppressing the activities elsewhere that may compete with the existing frontal end. Conversely, when negative signals are allowed to accumulate in the vicinity of positive signals, they cause negative feedback by overpowering positive signals.”The scientists suggest that microtubules are required not for the generation, but rather for the maintenance, of cell polarity by mediating the global distribution of inhibitory signals. “We found that after the depolymerization of microtubules, cells are still able to move directionally for more than an hour before reversing the direction,” Wang says. “Therefore, cells without microtubules are able to establish a direction of migration but are not able to maintain the polarity for an extended period of time as control cells do. The defect may be explained by the inability to remove the accumulating inhibitory signals at the leading edge, which eventually overpower the excitation signals required for maintaining frontal protrusion activities.”A key finding discussed in the paper is that disassembly of microtubules induces cell oscillation by allowing inhibitory signals to accumulate at the front, which stops frontal protrusion and allows the polarity to reverse. “According to the LEGI model, frontal protrusion activities are determined by the balance between excitation and inhibitory signals,” Wang explains. “Upon the loss of microtubules and the associated transport mechanism, the cell is no longer able to move inhibitory signals away from the leading edge where they are generated, and therefore cannot achieve their global distribution.” Specifically, the accumulating inhibitory signals eventually overcome the excitation signal to stop frontal protrusion activities – and at the same time, the suppression of protrusion activities elsewhere also becomes compromised due to the defective global transport. “Spontaneously-generated excitation signals are then allowed to accumulate and cause the formation of a new front,” Wang adds, “which in the case of cells confined to 1D translates into the reversal of polarity.” The researchers also found that in addition to oscillation, their modified LEGI mechanism can create a range of possible cell behaviors as a result of different relative dynamics of excitation and inhibitory signals – and thereby, the variable interplay between shape, mechanics, and polarity. “The magnitude of inhibitory signals is determined by the relative rate between the generation and transport-mediated depletion.” Wang adds. “Our model accounts for the key elements between signal generation and transport – and while previous models, such as that created by Brian Camley and his colleagues2, incorporate some of the relevant parameters such as cell adhesion and shape to generate oscillation, they are unable to generate as wide a range of activities.”Wang notes that their mathematical model is capable of generating testable, verifiable predictions. One of the primary predictions was that longer cells should oscillate with a longer period; another prediction was that inhibition of dynein (one of many proteins that bind to microtubules, in this case a motor protein responsible for the transports of cargos away from the cell front) should cause similar oscillations as those caused by microtubule disassembly. Wang emphasizes that both of these predictions were verified with experiments. , Physical Review Letters The scientists also faced a hurdle when applying computer modeling to understand how positive LEGI feedback might be converted into negative feedback to drive oscillations upon microtubule disassembly. “The main challenge was to model not only excitation and inhibitory signals at different locations, but also a transport process responsible for delivering the inhibitory signals away from the frontal region for global distribution,” Wang explains, “because the oscillation phenomenon can be produced only when the model includes all the essential elements.” © 2014 Phys.org , Physical Biology PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen Citation: Going places: Microtubule-mediated transport of inhibitory signals critical in stabilizing cell migration polarity (2014, December 9) retrieved 18 August 2019 from https://phys.org/news/2014-12-microtubule-mediated-inhibitory-critical-stabilizing-cell.html Journal information: Proceedings of the National Academy of Sciences Persistent migration of cells on 1D strips and the corresponding localization of focal adhesion proteins. Related to Fig. 1. Immunofluorescence staining of tensin in a representative RPE-1 cell (A; scale bar, 25 μm) shows no apparent polarization. Kymograph (B; scale bar, 50 μm, 60 min) and time series (C; 90-min interval; scale bar, 100 μm; arrow indicates the direction of migration) of representative NIH 3T3 fibroblasts exhibiting persistent migration on 1D strips. RFP-zyxin in NIH 3T3 cells migrating on 1D strips localizes to the tail region (D). (Scale bar, 50 μm.) Credit: Zhang J et al. (2014) Microtubules stabilize cell polarity by localizing rear signals. Proc Natl Acad Sci USA 111(46):16383-16388. , Journal of Cell Biology A new mechanism affecting cell migration found Despite the complexity of their investigation, the researchers addressed these challenges in a number of ways. They showed that microtubules play a key role in maintaining the positive feedback in the LEGI mechanism, and as described above that positive feedback of the LEGI mechanism for persistent migration may be readily converted into a negative feedback for oscillations. “We found that, in order to generate oscillation, the production of inhibitory signals must lag behind the production of excitation signals,” Wang tells Phys.org. “This is consistent with the general understanding that delay differential equations have the capability to generate oscillations.” In addition, he continues, they used a highly reliable micropatterning method, developed in their lab, which grafts linear polyacrylamide on glass surfaces to block cell migration for confining cell migration to a 1D strip. “We also used a computer model – also implemented in our lab – that simulates not only the control circuit, but also its effect on cell migration.”The paper presents two analytic conclusions, the first being that microtubules facilitate the transport of inhibitory signals and their global distribution. “Our reasoning was guided by the conversion from persistent migration – known to depend on LEGI-based positive feedback – to oscillation, which in general requires negative feedback,” Wang says. “The simplest way for this conversion to occur involves the inhibition of global distribution of negative signals, which fits perfectly with the well-documented function of microtubules in intracellular transport.” Wang points out that this type of reverse reasoning – where an intuitive hypothesis to provide a simple explanation of a biological phenomenon is made before seeking experimental evidence or computational verification – is widely practiced for understanding complex biological phenomenon that are too difficult to address through forward dissection. “Our results further imply that a cell is able to measure its own length based on the time required for end-to-end microtubule-mediated transport,” Wang continues. “Other cellular processes may be similarly affected by the time for the transport of molecular signals along the cell length.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Incoming England and Wales Cricket Board (ECB) chairman Colin Graves has given Kevin Pietersen a glimmer of hope that he may yet be able to resurrect his England career. Pietersen, 34, has not played for England since the ECB effectively called time on his international career following the disastrous Ashes tour of 2013-14.But with England toiling at the World Cup and Pietersen having spoken of his eagerness to return to the team, Graves has suggested that a return to English county cricket could open the door for a dramatic comeback. “The first thing he has to do if he wants to get back is start playing county cricket. The selectors and the coaches are not going to pick him if he’s not playing. It’s as simple as that. I’ll leave it at that,” Graves told BBC Radio 5 on Sunday. Also Read – Khel Ratna for Deepa and Bajrang, Arjuna for JadejaPietersen is currently without a county after leaving Surrey and although Graves is not an ECB selector, he believes a county return would help the outspoken South Africa-born batsman’s cause. Asked if he was in favour of Pietersen returning for England, Graves replied: “At the end of the day it’s down to the selectors and coaches and what they feel is best for English cricket. They will make the decisions and I will support their decisions.”
Bottoms up! Enjoy a cold one for International Beer Day (Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.) Arizona families, Arizona farms: A legacy of tradition embracing animal care and comfort through modern technology The difference between men and women when it comes to pain New Year’s resolution: don’t spend another year in a kitchen you don’t like 0 Comments Share It’s a theme Benedict has insisted on throughout his pontificate: that in today’s increasingly secular world, more and more people think they can live without God. Benedict has focused much of his teaching on trying to reverse that trend, trying to revive Christianity in parts of the world where it no longer takes center stage or where it has been damaged by scandal.In his previous Jesus books, Benedict made some sweeping proclamations, for example exonerating the Jews as a people for Christ’s death in “Jesus of Nazareth: Holy Week: From the Entrance into Jerusalem to the Resurrection,” which was published in 2011.There are no such headline-grabbing declarations in the slim, 127-page volume, which Benedict wrote this summer during his vacation at the papal residence in Castel Gandolfo, while the Vatican was convulsed with the scandal over his leaked documents.But he makes a few key points, many of them concerning the importance of Mary in the whole of Christianity, particularly her obedience in accepting to bear Jesus as a virgin.Benedict insists on the uniqueness of Mary’s “virgin birth” of Jesus, dismissing similar Egyptian and pagan Greco-Roman myths as paltry in comparison to the “profound” reality of Mary willingly accepting the word of an angel that she would bear the son of God. Sponsored Stories Top Stories Mary Coyle ice cream to reopen in central Phoenix The first two books, which topped the bestseller lists in Italy, dealt with Jesus’ public ministry and his death, leaving just Jesus’ birth to complete the series. More than 1 million copies are planned for the initial print run, just in time for Christmas.In the book, which the Vatican presented Tuesday, Benedict blends history, theology, linguistics and even astronomy to interpret the Gospels of Matthew and Luke, which describe the months just before and after Jesus’ birth.Benedict’s findings: Jesus was indeed conceived immaculately to Mary and was born poor, in a stable in Bethlehem. Yet he was revered by even his first visitors who brought him gifts befitting a king _ the first visitors of what would become billions of followers.Benedict laments that despite all the evidence pointing to Jesus as the savior of mankind, he remains a contradiction today _ a contradiction that in the end is directed at God.“God himself is constantly regarded as a limitation placed on our freedom, that must be set aside if man is ever to be completely himself,” Benedict writes. But he insists: “God, with his truth, stands in opposition to man’s manifold lies, his self-seeking and his pride. God is love.” Construction begins on Chandler hospital expansion project Former Arizona Rep. Don Shooter shows health improvement “Perhaps one could say that humanity’s silent and confused dreams of a new beginning came true in this event _ in a reality such that only God could create,” Benedict wrote.Benedict notes the poverty into which Jesus was born, forced to come into the world in a stable because there was no room for his parents at an inn. Benedict says that alone should cause Christians to reflect, as it points to a “reversal of values” found in Jesus’ figure.“From the moment of his birth, he belongs outside the realm of what is important and powerful in worldly terms,” he wrote.Yet Jesus’ first visitors were three wise men who brought him gifts for a divine king, as if they knew ahead of time the importance of this birth. Aside from the significance of their gifts, Benedict writes that the three represent the first followers who were drawn to Christ.“Not only do they represent the people who have found the way to Christ: they represent the inner aspiration of the human spirit, the dynamism of religions and human reason toward him.”___Follow Nicole Winfield at www.twitter.com/nwinfield Associated PressVATICAN CITY (AP) – Pope Benedict XVI completed his trilogy on the life of Jesus Christ with a new book on Jesus’ birth, insisting on its significance for Christians today and lamenting that God is still considered by many an obstacle to their freedom.“Jesus of Nazareth: The Infancy Narratives,” hits bookstores in 50 countries on Wednesday, the third and final installment of a project the 85-year-old Benedict conceived a decade ago and began writing soon after he became pope in 2005.