A Jan. 27 Canadian Press story, based on information from Restaurants Canada, stated that delivery and take-out accounted for eight per cent of sales for quick service restaurants and six per cent of full-service restaurants sales in Canada for the first quarter of 2018. In fact, those numbers are for delivery only.The Canadian Press
Since Saturday, the UN High Commissioner for Refugees (UNHCR) has been helping many of the 21,000 Sri Lankans who have fled recent fighting in the town of Muthur, where 15 aid workers from French organization Action against Hunger were recently killed execution-style. The incident drew strong condemnation from UN officials that was echoed today by UNHCR spokesperson Jennifer Pagonis, who called the murders “a dark page in the history of humanitarian work in Sri Lanka.” With displaced people taking shelter mainly in schools and mosques, sporadic fighting is still reported to be going on around Muthur. UNHCR staff “can hear gunfire from time to time,” Ms. Pagonis said. The agency, working through local non-governmental organizations (NGOs), has distributed 1,800 plastic sheets, 2,000 jerry cans and 2,000 mats to displaced people, and more aid is in the pipeline. But UNHCR has no access to Muthur, “where 4,000 people are said to be trapped, or to Eachchilanmpattai, where some 11,000 people are said to be in dire need of humanitarian help,” Ms. Pagonis reported. Before the latest outbreak of fighting between the Sri Lankan government forces and the rebel Liberation Tigers of Tamil Eelam (LTTE), more than 312,000 people had been displaced within Sri Lanka since 1983, some 67,000 of whom are being assisted by UNHCR.
AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email Canadian dollar heads higher amid positive, but muted Chinese data by Linda Nguyen, The Canadian Press Posted Jul 10, 2014 7:23 am MDT TORONTO – The Canadian dollar rose Thursday amid positive if lacklustre economic data from China and a slight increase in oil prices.The loonie gained 0.11 of a cent to 93.92 cents US.Overnight, China reported that its June exports grew 7.2 per cent in dollar terms from a year earlier, accelerating slightly from May’s seven per cent growth.The advance was a small sign of improvement for the world’s second-largest economy, but still left concerns over the country’s uneven recovery as imports remained muted amid weak domestic demand.“There’s a bit of optimism with China’s customs office expecting exports growth to accelerate in the third quarter. Imports could also pick up based on improving signs of manufacturing and services activity in the past two months,” said Ryan Huang, a market strategist at IG, said in a commentary.Meanwhile, Statistics Canada says its new housing price index rose 0.1 per cent in May, largely due to higher new home prices in the Prairie region. The Calgary area, where prices rose 0.8 per cent, recorded the largest monthly price advance among the municipalities covered by the survey.But the most anticipated economic data to come out this week will be the Canadian jobs report on Friday.“As we continue to look for signs of economic improvement, the picture around unemployment is critical,” said Tim Caulfield, co-lead manager at Franklin Bissett Canadian Equity Fund.Statistics Canada is expected to report that about 24,000 jobs were created last month compared with 25,800 in May, with the jobless rate remaining unchanged at seven per cent.The Canadian currency continues to look for hints that the fundamentals supporting it, including oil prices, will remain strong. Despite an uptick Thursday, oil has been falling steadily for more than a week as geopolitical concerns surrounding the world’s oil supply have eased.Political strife had shut ports and disrupted oil production in Libya. But recent agreements with local militias should see those ports reopening, while production began ramping up at a major Libyan oilfield earlier this week.Still, the August crude contract on the New York Mercantile Exchange climbed 64 cents to US$102.03 a barrel on Thursday, its first increase in two weeks.August gold bullion was up $14.90 to US$1,339.20 an ounce, while September copper rose two cents to US$3.27 a pound.Follow @LindaNguyenTO on Twitter.
TORONTO – Toronto’s runaway real estate market could take a breather due to Ontario’s new housing measures, but much like what transpired in Vancouver, the impact of the changes is expected to be short-lived, experts say.Premier Kathleen Wynne announced more than a dozen new initiatives aimed at reining in prices that have soared out of reach for many homebuyers, including a 15 per cent tax on non-resident speculators in the Greater Golden Horseshoe, a fast-growing region that stretches from the Niagara Region to Peterborough, Ont.The province is also expanding rent controls and giving Toronto and other municipalities the power to impose a tax on vacant homes, something that Toronto Mayor John Tory has been pushing for.“Ultimately at the end of the day, you probably end up in a situation where the market absorbs the tax and keeps pushing higher,” said BMO economist Robert Kavcic.Benjamin Tal, deputy chief economist with CIBC, said the measures are likely to cool the market over the next six months as many buyers will move to the sidelines to assess the fallout stemming from the changes.“That’s exactly what we’ve seen in Vancouver,” said Tal.“The slowdown in Vancouver was not entirely due to the tax — it was domestic buyers who were basically sitting on their hands waiting to see the impact of the tax.”Home sales plunged and price growth stalled for months in Vancouver following the B.C. government’s introduction of a 15 per cent tax on foreign buyers last August.But a recent report from realtor Royal LePage suggests the Vancouver market may be starting to bounce back as demand starts to return.That’s what experts are predicting will happen in Toronto.“A lot of local buyers will sit on the sidelines for a while to watch and see what happens, and then that pent-up demand will re-enter the market down the road once the fear and the unknown has passed,” said Blair Mackey, a sales representative with Royal LePage Real Estate Services.However, Kavcic said the impact in Toronto could be more muted than it was in Vancouver, as the tax is not coming as a surprise and there are more exemptions. For example, international students will not be subject to the tax.“We’ve already known for months that this was probably coming down the pipeline, versus Vancouver where you woke up one morning and there was a 15 per cent tax,” he said.Economists said they were somewhat surprised not to see any measures tackling domestic speculators, particularly considering the amount of discussion the topic had drawn.Such rules could still be coming, said Tal.“Domestic flippers probably will be the next target,” he said.Tal took issue with the province’s plans to expand rent control, which currently applies only to units built before November 1991, to all private rental units. The guidelines cap rental increases and in recent years the cap has averaged at two per cent. This year it is 1.5 per cent.“It’s coming from a good place,” said Tal.“You really want to protect tenants. The issue is that builders will tell you that if you impose rent control that is only as high as inflation, that is not enough for them to start building.”Tal said he suspects that over the next few years, builders who were planning to construct rental buildings will opt for condos instead or cancel the developments altogether, a move that would reduce the supply of rental units.A better measure would have been to cap rents at inflation plus one or two per cent, said Tal.“By doing so, you do provide tenants with protection. There is a cap. But at the same time, the number three, three-and-a-half, is actually the magic number for developers.”Follow @alexposadzki on Twitter. A construction worker shingles the roof of a new home in a development in Ottawa on Monday, July 6, 2015. Experts say measures introduced by the Ontario government to cool the red-hot housing market are likely to leave a lot of the buyers on the sidelines as they await to see the impact of the changes. THE CANADIAN PRESS/Sean Kilpatrick Ontario housing measures expected to have short-lived impact, experts say by Alexandra Posadzki, The Canadian Press Posted Apr 20, 2017 11:53 am MDT Last Updated Apr 21, 2017 at 7:40 am MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email
“Those Knicks teams — the ’69-’70 team, the ’72-73 team — when you talk to basketball purists about the greatest teams they’ve ever seen, that little era always comes up,” a radio voice intones early in Michael Rapaport’s “When The Garden Was Eden,” a “30 for 30” film debuting on ESPN Tuesday. “That’s the way you’re supposed to play basketball.”Speaking as a card-carrying basketball purist (or at least a basketball history nut), he’s right — particularly on that last point. The Knicks of that era rank highly among the all-time great NBA teams, but not at the very top. Instead, where they really stand out is in how they won.The 1969-70 New York Knicks, who won the first of the franchise’s only two championships, consistently rank among the most dominant regular-season teams in NBA history, especially relative to the spread of talent in the league at that time. After adjusting for strength of schedule, their per-game point differential was +8.4 (17th all-time); it also outpaced the second-place Milwaukee Bucks that year by 4.2 points per game, the sixth-biggest gap ever between the league leader and runner-up. That was a big part of why the Knicks’ schedule-adjusted scoring margin was 2.4 standard deviations better than the average team’s in 1969-70 — the second-best such mark ever.The 1969-70 Knicks struggled on the road in the playoffs and were taken the distance twice in the span of three series. But the team’s playoff run — which saw New York outlast the Baltimore Bullets (led by future Knick Earl Monroe), overpower a rookie Kareem Abdul-Jabbar and his Milwaukee Bucks, and survive the Los Angeles Lakers in a seven-game NBA Finals classic — also ranks among the 50 or so best ever, after taking into account whom they had to beat.And the 1972-73 Knicks did even better in the postseason after adjusting for their road to the championship. When I listed the most dominating playoff performances ever back in 2010, that team ranked 11th all-time. With the exception of the 2014 San Antonio Spurs, it’s unlikely that it has been supplanted by more recent champions. En route to the title, New York beat the Baltimore Bullets (+2.9 schedule-adjusted PPG differential) in five games, the Boston Celtics (+7.4) in seven, and the Los Angeles Lakers (an NBA-best +8.2) in five — just about the toughest path any team has ever gone through to win an NBA championship.But bottom-line results are only half the equation when aficionados rave about the Knicks of the early 1970s. Perhaps an even bigger factor is how the team achieved its success, with a reputation for playing one the most unselfish, pass-friendly styles in basketball history.This isn’t gauzy, New York-media-baked myth-making. Among historical NBA champions, the 1972-73 Knicks rank 14th in assist percentage (the ratio of made baskets that were assisted) relative to league average. And, more importantly, they had the most balanced distribution of shot attempts among their starting five players of any championship team ever. During the 1973 playoffs, their leading scorer (the incomparable Walt Frazier) took 20.8 percent of the team’s shots when on the floor, while the fifth-ranked shooter among its starters (Bill Bradley) took 18.7 percent. By comparison, the 1992 Chicago Bulls’ leader — Michael Jordan — took 37 percent of that team’s shots when on the floor, while Bill Cartwright took 11 percent. (Coincidentally, that Bulls team was coached by early-’70s Knicks forward Phil Jackson.)My research shows that most NBA champs are more like Michael and the Jordanaires than Frazier, Bradley, Earl Monroe, Dave DeBusschere and Willis Reed. Historically, teams with an uneven distribution of the offensive workload — particularly with regard to the difference between their top two scoring options and the rest of the starting five — tend to win championships at a much higher rate than teams that spread their shots around more equally.That they bucked this trend is probably the lasting legacy of the Red Holzman-coached Knicks. In a sport dominated by singular scorers like Jordan (usually with good reason), New York showed that there’s also a place for unselfish, collectivist basketball in the circle of NBA champions. And as my colleagues Ben Morris and Rafe Bartholomew have noted, the San Antonio Spurs (winners of the 2014 NBA championship) have carried the torch for this phenomenon in recent years.With the 2014-15 NBA season tipping off next week, the Knicks are unlikely to add a third championship banner to Madison Square Garden’s rafters. But Rapaport’s film will recall fond memories of a time when basketball-crazed New York City was the center of the sport’s universe.
Already popular in North America and Europe, dry-type transformers will soon be seeing greater take-up in Africa through a more concerted entry and support strategy from global leader Hammond Power Solutions (HPS). According to Andrea Giacometti, Regional Sales Manager of HPS Europe, the company’s recent acquisition of key technology pioneers Euroelettro Hammond and Marnate Trasformatori in Italy has placed the company in a strong position to grow into Asia and Africa. It also acquired PETE in India, a leading manufacturer of power and distribution transformers in Andhra Pradesh.“As the world’s largest producer of dry-type transformers, HPS’s Italian acquisitions have led to a strong technology base in Europe from which we have already expanded into Asia,” says Giacometti. “The technical excellence of our plants in Canada, US, Mexico, Italy and India give us the ability to recommend and apply the right solution for a range of applications and industries.”Marnate, for example, has manufactured dry-type transformers since the 1970s and has been at the forefront of cast-resin technology. As with HPS’s other facilities, it operates at the highest levels of quality and safety, compliant with global standards and certified by international bodies like CESI and TUV.He says HPS Europe is now working closely with Trafo Power Solutions in South Africa to boost its Africa footprint in a strategic and forward-looking manner.“At HPS, we develop our products in line with our customers’ applications and needs,” he says. “The real innovations in this field are not just the technology itself, but the way we apply these technologies with our customers. We work with our customers to find solutions.”David Claassen, Managing Director of Trafo Power Solutions, highlights that flexibility is the focus in the way that both HPS and Trafo approach their work. “The application will determine the enclosure design and the transformer design,” says Claassen. “In our modus operandi, ‘one size fits all’ definitely does not apply.”In fact, Trafo Power Solutions does not see itself as simply a distributor of products. In line with the approach that HPS has always adopted, it is a solutions-driven company.“We work with customers to engineer technically appropriate and proven solutions for their applications,” he says. “HPS has longstanding experience in a host of technologies, which matches well with my experience in working with various sectors and applications around Africa.”Responding to the trend towards greater use of renewable energy, HPS Europe has developed several dry-type transformers for renewable energy markets such as photovoltaic, wind and biomass co-generation. Already, their impregnated transformers and inductors are installed in many inverter cubicles used in the conversion of wind or solar energy. “This will most certainly be a growth area for Trafo Power Solutions in Africa, as we see growing investment in energy generation from renewable sources,” says Claassen. “Renewable energy is a very demanding application for any transformer; ambient temperatures tend to be high and the environment is often dusty. These transformers supply a 100% non-linear inverter load that is high in harmonics.”This requires high levels of technical capacity and experience in terms of structural design, heat dissipation and electrical characteristics specification. Trafo Power Solutions is well placed to take advantage of these opportunities as HPS has already supplied hundreds of units into these conditions.Among the core benefits of the dry-type transformer design is its safety and cost-effectiveness. Due to the absence of oil as a coolant, the dry-type transformer is simple and safe, allowing it to be installed indoors without its own civils infrastructure.
EVERYONE’S FAVOURITE ASTRONAUT Chris Hadfield has tweeted this image of Berlin as seen from the International Space Station, highlighting the east/west divide.The contrast is due to different lightbulbs used on either side of the city, due to different street lighting systems, and gas lamps still in use in parts of Berlin.@Cmdr_HadfieldCERN’s Hadron ColliderAccording to Commander Hadfield “Under that rock (in Geneva, Switzerland) is the incredible CERN particle accelerator”.The India/Pakistan borderThe border between the two countries is clearly illuminated by security floodlights. Image: NASAA thunderstorm An agricultural project in LibyaLas VegasSurrounded by desert, Las Vegas stands out.. Image: NASA/Wikimedia CommonsMt EtnaCommander Hadfield says:Our Earth is mostly liquid rock. We live on a thin crust, with occasional hot spots, like Mt. Etna. The border of USA and MexicoThese man-made islands in Dubai All images @Cmdr_Hadfield unless otherwise indicated How fast is the internet in space? 8 things we learned from an astronaut’s son>New app stops you having sex with your cousin>13 high fives you’ll definitely want to be in on>
People are constantly making interesting, if slightly offbeat combinations of devices. For instance, spider silk and goat milk can make human skin bulletproof. Rene Grau’s combination isn’t as offbeat, but it’s arguably practical if you have a heavy PC rig to transport around. He managed to combine a CoolerMaster HAF X gaming computer with a gas-powered mini bike while managing to retain the ability to ride the bike.The computer isn’t just there for show. It’s a fully functional machine comprising an Intel Core i5 processor, 300GB SSD, and a 4GB GeForce GTX 460 graphics card. The bike is fully functional, too. It has a two-stroke engine and dual exhaust with speed peaking at around 40 mph with the heavy PC and driver on board. With a computer attached, it looks like an uncomfortable machine to ride as the handlebars are well below the top of the tower, but a difficult ride is better than tired arms carrying that case for miles.The video below shows the HAF X mod in action. There doesn’t appear to be a cushion, and the tower itself is less that ideal as a seat, especially as balance and weight shifting will be required too. So this is a setup purely for a local LAN party, not longer trips.It does take a good amount of technical know-how to make this combination work, but I don’t see many practical applications beyond transporting you rig for a gaming session at a friend’s house or local tournament. There’s also the fact it’s going to be a talking point wherever you ride it.via Technabob
Unicef says ‘world is failing newborns’ as global baby mortality rates remain ‘alarmingly high’ Ireland has ranked 164th in the global neonatal mortality rate. Tuesday 20 Feb 2018, 6:10 AM By Hayley Halpin Share103 Tweet Email 16 Comments A baby at a Neonatal Intensive Care Unit in Ethiopia Feb 20th 2018, 6:11 AM http://jrnl.ie/3860876 Short URL GLOBAL DEATHS OF newborn babies remain alarmingly high, particularly among the world’s poorest countries, Unicef has said.The organisation’s new report on newborn mortality rates globally – Every Child Alive – has found that babies born in Japan, Iceland and Singapore have the best chance at survival.In contrast, newborns in Pakistan, the Central African Republic (CAF) and Afghanistan face the worst odds.One in every 22 babies dies in Pakistan, one in every 24 in CAF, and one in every 25 in Afghanistan. However, just one in every newborn 1,111 in Japan dies, and one in every 1,000 in Iceland.Ireland has ranked 164th in the global neonatal mortality rate (using median value). In 2016, one in every 455 newborn died. Source: UnicefAround the worldGlobally, in low-income countries, the average newborn mortality rate is 27 deaths per 1,000 births. In high-income countries, that rate is three deaths per 1,000.The report also notes that eight out of the 10 most dangerous places to be born are in sub-Saharan Africa, where pregnant women are much less likely to receive assistance during delivery due to poverty, conflict and weak institutions.Unicef said that if every country brought its newborn mortality rate down to the high-income average by the year 2030, a total of 16 million lives could be saved.More than 80% of newborn deaths are due to prematurity, complications during birth or infections such as pneumonia and sepsis, the report said.Unicef said that some of these deaths could be prevented with access to well-trained midwives, along with clean water, disinfectants, breastfeeding within the first hour, skin-to-skin contact and good nutrition.However, a shortage of well-trained health workers and midwives in many countries has meant that thousands don’t receive the life-saving support they need to survive.For example, Unicef outlined that while there are 218 doctors, nurses and midwives in Norway to serve 10,000, that ratio is one per 10,000 in Somalia.“While we have more than halved the number of deaths among children under the age of five in the last quarter century, we have not made similar progress in ending deaths among children less than one-month-old,” Henrietta Fore, Unicef’s executive director said.“Given that the majority of these deaths are preventable, clearly we are failing the world’s poorest babies,” she said.This month, Unicef is launching its Every Child Alive global campaign in a bid to demand solutions on behalf of the world’s newborns.“Every year, 2.6 million newborns around the world do not survive their first month of life. One million of them die the day they are born,” Forde said.“We know we can save the vast majority of these with affordable, quality health care solutions for every mother and every newborn. Just a few small steps from all of us can help ensure the first small steps of each of these young lives.”Read: Oxfam chief executive says criticism over prostitution scandal has been ‘disproportionate’More: Transgender woman able to breastfeed in first recorded case Tweet thisShare on FacebookEmail this article 7,703 Views A baby at a Neonatal Intensive Care Unit in Ethiopia Image: Mulugeta Ayene via Unicef Image: Mulugeta Ayene via Unicef
In his 2009 predictions to FOLIO:, Bob Sacks, president and publisher of Precision Media Group, said that this would be “the year that e-paper finally got the respect and understanding it deserves. The introduction in early 2009 of the Plastic Logic full sized, touch screen, e-reader will be the forerunner of this recognition.”While in the past e-readers like Amazon’s Kindle and Sony’s Reader have been primarily focused on book publishing, Hearst Corporation recently announced that it will debut a magazine e-reader later this year.The first American magazine publisher to directly tap the digital reader market, Hearst is encouraging others to license technology so that they, too, can deliver digital content. Hearst is looking at a design better suited for reading magazines and newspapers than the book-focused Kindle. Those close to Hearst’s e-reader project say that the device is light, with a large screen to make digital reading as comfortable as the print products, at 8.5×11 inches versus the Kindle’s six-inch screen. Mountain View, California-based Plastic Logic also has plans to launch a new electronic reading device in 2010, and through a partnership with digital vendor Zinio will provide magazine content.It’s been suggested that, if successful, an e-reader could someday replace print magazines and save of approximately 50 percent of the expense involved by cutting paper, printing and delivery costs. e-reader digital screens also save power by displaying changeable text and images.On Esquire’s blog, editor-in-chief David Granger wrote that he is hopeful that new electronic reading devices would save not only the suffering newspaper and magazine industries, but reintroduce people to the pleasures of reading in general: “As electronic readers improve, as they add graphics and design and, eventually, color, even more people will opt for the more sustained, contemplative experiences more often.”VITAL STATS: If successful, an e-reader could someday replace print magazines with savings of approximately 50 percent for paper, printing and delivery costs.
WILMINGTON, MA — Below is an op-ed submitted by State Rep. Candidate Dave Robertson (D-Tewksbury):Over the last few days there has been great media coverage of a long-time issue here in Massachusetts; the release of repeatedly violent criminals who have continued to live a life of crime. Most recently, Judge Tim Feeley released Manuel Soto-Vittini, a longtime heroin dealer, by claiming his crimes were financially based, as if it was similar to providing bread to his family. This, of course, ignores all those who potentially overdosed or had their lives destroyed by Soto-Vittini’s poison. Only a few weeks before Massachusetts lost one of its finest, Officer Sean Gannon. This was by a criminal who started dealing drugs and robbing individuals as a teenager, and deserves no mention by name. I could continue listing heartbreaking issues such as these, but it would take up far too much space. What is apparent is the system needs to be examined.Over the next few weeks you’ll likely hear a pitch that sounds good, and appears to be a silver bullet when it comes to oversight on judges ruling. This, of course, is directly elected judges. There are many aspects of this touted to be better, such as accountability to the general public, which Massachusetts currently lacks. However, when one looks closer at this issue, many issues and flaws with this suggestion also come to late. In fact, elected judges were first brought to the ballot early last century to increased judicial independence, striking down more laws than many who preceded them and upholding criminal accountability by following the rule of law, rather than letting certain folks off due to political patronage. Over the past century, this system has completely reversed itself and when measured, has become more corrupt than appointed judges.Professor Jed Shugerman, a graduate of the top-ranked Yale Law School and now a professor at Fordham, did a terrific in-depth study of elected judges that eventually he published into a book. Through his research he found out that since elected judges must appeal to contributors, judicial rulings become compromised when certain favorable parties appear before the bench. In addition, elected judges have a much higher percentage of their rulings overturned by superior courts, showing that elected judicial authorities choose the correct ruling at rates below those of an appointed counterpart. This research has been since confirmed by Emory University, NYU, and the non-partisan Constitution Center. In Michigan, a battleground state with an even split among Democrats and Republicans, over 13 million dollars was contributed to judge campaigns. With that sort of money floating around, how can justice be fair from either side?So what can we do to clean up our act here in Massachusetts? Long-time, Reagan-appointed Supreme Court Justice Sandra Day-O’Connor actually has a brilliant, common-sense solution. First appoint, like Massachusetts does, then wait and let the judge work. After a certain term, Justice Day-O’Connor suggests, have voters elect these judges back to power if they are doing a good job in the eyes of the public. This hybrid plan is ingenious for several reasons. Political appointments are often more-vetted and experienced, guaranteeing a higher quality of judgeship that elected states fail to maintain. In addition, the removal of any ballot races aside from accountability removes the potential corruption that money donated to judges would otherwise risk. When a judges term is up, say every 7 years as suggest by Justice Day-O’Connor, voters face a simple choice based on the judge’s track record and no more. There are no competitors and no need to raise money, it’s time to send them back to the bench or for the Governor and their council to pick a new appointee.This balanced, while sensible, approach would bring to Massachusetts what we in the state need; accountability. In addition to allowing us regular folks to hold those in government accountable, it preserves the higher quality of rulings that the majority of judges, who tend to do a good job overall, bring to the courts. In addition, it insulates us from potential corruption that many elected judges show, and ensures that in several years we won’t be reading about an elected judge because they let off the relative of their largest donor, who actually was “only selling heroin to get by.”Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedSTATE REP RACE: Tewksbury Republican Committee Attack Robertson Over Wilmington Democratic Committee Chair’s StatementIn “Government”ALL POLITICS ARE LOCAL: Robertson & Gordon Endorse Ed Markey With Possible Kennedy Showdown LoomingIn “Government”STATE REP RACE: Prinzivalli Campaign Declares Debate Victory; Knocks Robertson On Dandi-Lyons & Sanctuary StateIn “Government”
Nagarkurnool: PCC working president Revanth Reddy on the Sunday urged people to unite so that the State and Central governments do not dare to encroach upon their lands for uranium mining. Addressing the people in Chenchu pentas of Amrabad mandal of the district, Revanth said that the State and central governments are trying to remove the poor tribal of Chenchus from the forest areas and designing cruel plan to take over their lands for the uranium mining. Also Read – Car mechanic held in Hyderabad for killing Class 10 girl in Jadcherla Advertise With Us “Chenchus must keep themselves united. We are here to support your cause and protect your rights and fight against the encroachment of Nallamalla forest. If you are united we will stand by you, even if they bring battalions of force they cannot do anything,” said Revanth while creating awareness to the Chenchus on the State and Central government’s plans to evacuate the poor Chenchus from the forest. Also Read – Techie strangled to death in Hyderabad Advertise With Us Revanth said that on one hand the government is spending thousands of crores of rupees for the Haritha Haram to grow trees, on the other, here is a case where they are coming forward to cut down the trees of hundreds of years of old age and want to destroy the Nallamalla forest and the surrounding region in the name of uranium mining. Uranium mining will not only pollute the air, water and land but also destroy the entire environment in the Nallamalla region. He advised the Chenchus to get united and fight against the nefarious designs of the State and Central governments. Advertise With Us The State Congress working president said that the government through the Forest department has already started removing more than 100 tribal tiger trackers from the Chenchu communities who were appointed to track the tigers in the forest. Now by removing them the government has ruined their livelihood. A Chenchu tribe while requesting the leaders urged them to help them protect their culture and livelihood. Some Chechus who complained of lack of drinking water were also promised by Revanth that very soon he would dig a bore well for them to provide the drinking water for the Chenchu penta.
As sure as the Sun sets in the west, Nintendo will remake past Pokémon games, slap new words in front of the original titles, and give them a fresh coat of pixelated paint. With last year’s Pokémon X and Y, the series finally made its way to the medium of animated critters and 3D (in both character models and limited Nintendo 3DS gimmick). Now, it’s time for Nintendo to dump a bucket of paint on an older Pokémon generation as is tradition, this time in the form of Omega Ruby and Alpha Sapphire — and no, we don’t know why Omega gets first billing.These two remade installments will be landing some time in November, just a little over a year after the October 12 release of Pokémon X and Y. We haven’t seen much of the game in action yet, and this teaser first shown in Japan is all we really have so far.As you can see from the above teaser, nothing is really revealed other than the animations of the game’s cover athletes. If you have the volume turned up, the teaser is set to a soundtrack of awkward rumbling noises that sound more like your headphones are broken than an accompanying soundtrack. It looks as though these remakes will sport the same graphical style of X and Y, which is good news for fans.The original Ruby and Sapphire released back in 2003 in North America (and 2002 in Japan) for the Game Boy Advance, kicking off the next-gen of Pokémon games, much in the same way X and Y did for the Nintendo 3DS. The story follows Team Magma and Team Aqua as the villains, using the games’ cover legendary Pokémon to dry up the oceans or flood the world, respectively.Stay tuned for more info when Nintendo drops it.
© 2019 Science X Network ABF locally perturbs fluid flow. (A) Schematic of a 200-μm-wide microfluidic channel with suspended ABF (36 μm long, 10 μm in diameter) positioned at the channel center (x,y,z) = (0,0,0). The upper channel contains water, whereas the lower channel contains 200-nm fluorescent NPs. (B) Snapshot of ABF in a 200-μm-wide channel perturbing the tracked paths of the 200-nm fluorescent NPs indicating fluid flow. Scale bar (top), 10 μm. A numerical simulation of two-fluid flow with an ABF at the interface, with color indicating concentration distribution (red, 1 mol/m3; blue, 0 mol/m3) of molecular species (bottom). (C) Velocity profile at positions upstream and downstream of the ABF. For the control, at x = +3 mm, an unperturbed laminar profile with peak velocity of 50 μm/s was simulated. At both x = +50 μm (upstream) and x = −50 μm (downstream), an increase in peak velocities is predicted, with the peak shifted closer toward the channel wall for the upstream case. (D) Simulation results for the y velocity component uy (orthogonal to and out of the channel) at the same positions as (C). In the vicinity of the ABF, a push directed orthogonal to the flow direction toward the channel wall is predicted. Credit: Science Advances, doi: 10.1126/sciadv.aav4803 Explore further Tiny robots powered by magnetic fields could help drug-delivery nanoparticles reach their targets Generally, NP transport is affected by surface charge, hydrophobicity and surface biochemistry; properties that can be actively optimized in research work for more effective in vivo trafficking. Scientists have used external energy sources such as magnetic and acoustic forces to create wirelessly controlled microbots and shuttle the therapies to diseased tissue for improved diffusive transport. However, these methods still relied on diffusive transport after releasing their onboard cargo, while the need remains for more distinct strategies of transport into a defined location. Control of green fluorescently labeled MTB in microfluidic device, when RMF is on/off. Credit: Science Advances, doi: 10.1126/sciadv.aav4803 Conceptual overview of magnetically controlled micropropellers for convection-enhanced NP transport. (A) Conceptual schematic depicting a single microrobot, the artificial bacterial flagellum (ABF), enhancing mass transport of nanoparticles (NPs) at the vessel-tissue interface (left), and swarms of magnetotactic bacteria (MTB) generating convective flow to improve mass transport (right). ECM, extracellular matrix. (B) Schematic of magnetofluidic platform for NP mass transport studies using magnetically induced convection. The microfluidic chip is placed between the objective lens of an inverted optical microscope and the electromagnets (left). A schematic depicts the chip, consisting of an upper channel filled with NPs (red) and a lower water channel (blue) that both border a collagen matrix (gray) along restricting trapezoidal posts made of PDMS. NPs can passively diffuse into the collagen matrix along their concentration gradient toward the water channel. Credit: Science Advances, doi: 10.1126/sciadv.aav4803 Ferrohydrodynamic pumping with controlled swarms of MTB. (A) Transmission electron micrograph of M. magnetic strain AMB-1. Scale bar, 0.5 μm. The magnetosomes are clearly visible, here formed in two distinct strings of iron oxide crystals. (B) Control of AMB-1 under static magnetic fields (top) and magnetic fields rotating in-plane at 1 Hz. Scale bar (bottom), 5 μm. (C) Postprocessed images of tracked, co-suspended, nonmagnetic, fluorescent NPs used to observe flow fields generated by a swarm of MTB exposed to a 12-mT magnetic field rotating at 10 Hz in the y-z plane. Traces in green correspond to traveled trajectories over 12 frames (~1 s). Positions are computed using band-pass filter with 25-pixel diameter, followed by peak finding (top). Bacterial motion can be steered by changing the direction of the vector of the rotating magnetic field, because the MTB translate within the plane of rotation (bottom). For an RMF vector around the x axis, bacteria rotate along y, generating a flow that transports NPs along y. (D) Translational velocity is plotted versus applied rotational frequency at two different magnetic field strengths. Translational velocity increases with frequency initially, but at sufficiently high frequencies, it decreases because fluidic drag torque overcomes the magnetic torque to prevent them from keeping up with the rotation of the field. The maximum synchronized frequency, also corresponding to the maximum translational velocity, is referred to as the step-out frequency ωmax. When the magnetic field strength is increased, the step-out frequency increases, as observed. Credit: Science Advances, doi: 10.1126/sciadv.aav4803 , Advanced Materials The scientists also developed a single-fluid flow model in a microchannel to form a bioinspired microvessel with biomimetic scales and fluid flow rates. The model contained concentrated collagen in the center that mimicked the native extracellular matrix. Using the device, Schuerle et al. quantified the fluorescent intensity in the biomimetic matrix to test if the magnetically controlled ABF could enhance the mass transport of fluorescently labelled NPs into the tissue-mimicking matrix. The results indicated that ABFs were limited as a convective micropropller in smaller vessels, but this can be changed by scaling the ABF structure to suit the channel size in the future.The scientists considered the effects of a whole swarm of smaller microrobot propellers next. For this, Schuerle et al. selected the wild type MTB strain AMB-1 (Magnetospirillum magneticum) to form magnetosomes. The microorganisms naturally produced chains of iron oxide particles in lipid bilayers of the plasma membrane for manipulated movement using external magnetic fields. While researchers had used MTBs in previous studies as potential vehicles of drug delivery with external magnetic fields, Schuerle et al. used rotational magnetic fields (RMFs) in the present work. The RMFs forced the movement of an MTB swarm to drive their motion via magnetic torque. , Nature Nanotechnology The scientists lowered the average distance between the bacteria by using a high concentration of MTBs to press the cell neighbors forward in 3-D swarms dominated by hydrodynamic forces. They did not observe clustering or aggregation of the MTB magnetosomes when exposed to RMFs since the magnetosomes were inherently shielded by the bacterial cell membranes for controlled fluid flow. Schuerle et al. repeated the experiments for biomimicry using a microfluidic device containing collagen to show that MTB swarms could penetrate collagen, when sufficiently high concentrations of MTBs were used. In this way, using two experimental strategies Schuerle et al. improved the mass transport of NPs, via convective flow generated by magnetically controlled micropropellers. The microrobotic experiments showed that ABF mimicked a bacterial flagellum to assist NP accumulation and penetration into a dense collagen matrix – when acted upon by RMFs. Schuerle et al. propose to include such stationary ABFs into stents to trigger drug release and improve penetration at a site of interest to counteract inflammation on demand. With the second strategy, they focused on generating the same technique but with magnetotactic bacterial strains (MTBs). Based on the present work and the existing tumor-homing properties of MTBs, the scientists envision magnetically controlled swarms of 3-D MTBs to transport NPs in the interstitial fluid space of tumor microenvironments. The scientists will optimize the density of bacteria for a compatible dose in vivo and the work will pave the way forward to further studies on micro- and nanomaterials for magnetically enhanced NP transport in clinical nanomedicine. They used rotating magnetic fields (RMFs) to power the devices and create local fluid convection to overcome the diffusion-limited transport of nanoparticles. During the first experimental approach, they used a single synthetic magnetic microrobot as an artificial bacterial flagellum (ABF) and then used swarms of a naturally occurring magnetotactic bacteria (MTB) to create a “living ferrofluid” by exploiting the ferrohydrodynamics. Using both approaches the scientists enhanced the transport of NPs in a microfluidic model of blood extravasation (movement of a drug from blood vessels to the external tissue) and tissue penetration in microchannels surrounded by a collagen matrix to create a biomimetic tissue-vessel interface in the lab. The results of the study are now published in Science Advances. Nanoparticles (NPs) are increasingly popular in nanomedicine due to biomedical research potential as carriers in drug delivery that surpass the limits of conventional medicine. While NPs are designed to alter the pharmacokinetics and biodistribution of existing drugs, they are impeded by physiological barriers, which prevent successful accumulation at the sites of disease, limiting their therapeutic effects in vivo. During cancer therapy, for instance, drug carriers encounter abnormal vessels that surround the tumor architecture for ineffective intravenous drug release. Since delivering NPs into tissues is strongly influenced by their physiochemical properties, scientists have re-designed the NP shapes and sizes to optimize their transport kinetics through vessel walls to reach tissues. Researchers had previously proposed multistage approaches for optimized drug delivery, either by shrinking nanoparticles in time, or fragmenting them to disperse and reach a site of interest only after encountering microenvironmental cues of disease in vivo. , Science Schuerle et al. engineered the magnetic ABF using three-dimensional (3-D) lithography and metal deposition, as previously reported. The bioinspired microrobots mimicked the rotating flagella for efficient propulsion-based locomotion at the microscale—where viscous drag forces dominate. They controlled the ABF motion with uniform magnetic fields in 3-D rotation using a wireless magnetic control setup containing electromagnets arranged around a single hemisphere. Then they mounted the setup on an inverted microscope to track the movements of the controlled microrobots. The rotating magnetic fields (RMFs) allowed forward propulsion and convective flow in the surrounding fluid and when the scientists immersed the ABF in a suspension of fluorescent NPs, they observed controlled flow for mass transport of the NPs.In the experiment, they constructed the bottom layer of the microfluidic channel to contain the 200 nm NPs similar to the size used in clinical applications, while on the top fluid layer they maintained a suspension of pure aqueous medium. The scientists stationed the ABF at the center of the setup to sustain its position against the flow by controlling the fluid flow in the setup. This arrangement of the ABF in a microfluidic channel disrupted the laminar flow to produce convection, which transported NPs from the fluid layer at the bottom to the upper layer—to reach the channel wall, i.e., the location of interest. The artificial bacterial flagellum (ABF) in a microvessel-like one-fluid flow device. Credit: Science Advances, doi: 10.1126/sciadv.aav4803 Nanoparticles (NPs) are a promising platform for drug delivery to treat a variety of diseases including cancer, cardiovascular disease and inflammation. Yet the efficiency of NP transfer to the diseased tissue of interest is limited due to an assortment of physiological barriers. One significant hurdle is the transport of NPs to precisely reach the target tissue of interest. In a recent study, S. Schuerle and a team of interdisciplinary researchers at the departments of Translational Medicine, Biophysics, Engineering Robotics, Nanomedicine and Electronics, in Switzerland, the U.K. and the U.S. developed two distinct microrobot-based micro-propellers to address the challenge. More information: S. Schuerle et al. Synthetic and living micropropellers for convection-enhanced nanoparticle transport, Science Advances (2019). DOI: 10.1126/sciadv.aav4803 R. Blakemore. Magnetotactic bacteria, Science (2006). DOI: 10.1126/science.170679 Ouajdi Felfoul et al. Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions, Nature Nanotechnology (2016). DOI: 10.1038/nnano.2016.137 Soichiro Tottori et al. Magnetic Helical Micromachines: Fabrication, Controlled Swimming, and Cargo Transport, Advanced Materials (2012). DOI: 10.1002/adma.201103818 In the present work, Schuerle et al. detailed two distinct strategies to generate wirelessly localized convective flow to prevent the invasiveness of implanted nanoparticles. Inspired by the field of microrobots (microbots), the scientists used (1) a single, synthetic, bacteria-inspired microrobot, or (2) large swarms of living bacteria to drive localized NP transport. The artificial and natural micropropellers assisted the process by promoting magnetically driven convection into a defined location in a magnetofluidic setup with potential for therapeutic applications. The synthetic microbot imitated bacterial propulsion using an artificial bacterial flagellum (ABF), while the dense swarms of magnetotactic bacteria (MTB) harnessed by Schuerle et al. occurred naturally as gram-negative prokaryotes (Magnetospirillum magneticum) with magnetic properties. The scientists expect the results to overcome existing transport barriers for enhanced NP tissue penetration via wireless control and spatiotemporally precise local convection in the future. Journal information: Science Advances Citation: Synthetic and living micropropellers support convection-enhanced nanoparticle transport (2019, May 7) retrieved 18 August 2019 from https://phys.org/news/2019-05-synthetic-micropropellers-convection-enhanced-nanoparticle.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
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